Age-dependent histopathological findings in the prostate of probasin/SV40 T antigen transgenic rats: Lack of influence of carcinogen or testosterone treatment
Age-dependent histopathological findings in the prostate of probasin/SV40 T antigen transgenic rats: Lack of influence of carcinogen or testosterone treatment
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DOI：
10.1111/j.1349-7006.2003.tb01412.x
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发表时间：
2003-02-01
期刊：
影响因子：
5.7
通讯作者：
Shirai, T
中科院分区：
文献类型：
--
作者：
Cho, YM;Takahashi, S;Shirai, T
在 Probasin/猿猴病毒 40 (SV40) T 抗原转基因 (TG) 大鼠中检查了前列腺病变表型的连续变化以及额外的致癌物治疗或去势对前列腺癌发生和进展的影响。 15 周龄时，所有叶中均出现明显的非侵袭性前列腺腺癌。此时侵袭性肿瘤仅限于前叶，此后以年龄依赖性方式在所有叶中发现。在任何年龄都没有明显的转移。额外的致癌剂治疗或去势不会促进激素非依赖性前列腺癌细胞的进展或产生选择性生长。这些结果表明，我们的TG大鼠适合阐明前列腺癌变早期的机制，即从前列腺上皮内瘤变（PIN）到非侵袭性病变再到侵袭性病变。 （癌症科学 2003；94：153-157）。
Sequential changes in the phenotype of prostatic lesions and the impact of additional carcinogen treatment or castration on development and progression of prostate cancers were examined in probasin/simian virus 40 (SV40) T antigen transgenic (TG) rats. Non-invasive prostate adenocarcinomas were evident in all lobes at 15 weeks of age. Invasive tumors were limited to the anterior lobe at this time point and were found in all lobes in an age-dependent manner thereafter. No metastasis was apparent at any age. Additional carcinogen treatment or castration did not enhance progression or generate selective growth of hormone-independent prostate cancer cells. These results suggest that our TG rats are suitable for clarification of mechanisms in early stages of prostate carcinogenesis, that is, from prostatic intraepithelial neoplasia (PIN) to non-invasive and then invasive lesions. (Cancer Sci 2003;94:153-157).