Correlation of Collagen Triple Helix Repeat Containing 1 Overexpression With Lymph Node and Peritoneal Metastasis in Epithelial Ovarian Cancer
Correlation of Collagen Triple Helix Repeat Containing 1 Overexpression With Lymph Node and Peritoneal Metastasis in Epithelial Ovarian Cancer
复制标题
胶原蛋白三螺旋重复序列1过表达与上皮性卵巢癌淋巴结、腹膜转移的相关性
DOI：
10.1097/igc.0000000000000850
复制
发表时间：
2017-01-01
影响因子：
4.8
通讯作者：
Lou，Ge
中科院分区：
文献类型：
--
作者：
Yang，Chang;Liu，Tianbo;Lou，Ge
目的探讨胶原蛋白三螺旋重复序列1（CTHRC 1）是否是卵巢上皮性癌腹膜和淋巴结转移的预测因子。材料与方法Westernblot分析显示CTHRC 1在大部分转移灶组织中呈高表达。单因素和多因素Logistic回归分析显示CTHRC 1过表达与卵巢上皮性癌的腹膜转移和淋巴结转移有关。结果CTHRC 1染色对淋巴结和腹膜转移的阴性和敏感性预测值均较好。高与低染色对腹膜转移的优势比为2.250（95%可信区间，1.126-4.496），对淋巴结转移的优势比为13.102（95%可信区间，6.036-28.439）。结论胶原蛋白三螺旋重复序列1可单独或联合其他标志物作为卵巢癌临床进展的预测指标。
Objective This study aimed to reveal whether collagen triple helix repeat containing 1 (CTHRC1) was a predictor of peritoneal and lymph node metastases in epithelial ovarian cancer, which had not been researched by others previously. Materials and Methods Western blot analysis showed that dramatic overexpression of CTHRC1 could be seen in most metastatic tissues. Univariate and multivariate logistic regression analyses demonstrated that overexpression of CTHRC1 was linked with peritoneal dissemination and lymph node metastasis in epithelial ovarian cancer. Results The negative and sensitivity-predictive values of CTHRC1 staining were excellent for both lymph node and peritoneal metastases. The odds ratio of high versus low staining for peritoneal dissemination was 2.250 (95% confidence interval, 1.126–4.496), and that for lymph node metastasis was 13.102 (95% confidence interval, 6.036–28.439). Conclusions Collagen triple helix repeat containing 1 may potentially be used as a predictive marker of clinical progression in ovarian cancer either alone or in combination with other markers.