Age exacerbates HIV-associated white matter abnormalities.
Age exacerbates HIV-associated white matter abnormalities.
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DOI：
10.1007/s13365-015-0386-3
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发表时间：
2016-04
影响因子：
3.2
通讯作者：
Cohen RA
中科院分区：
文献类型：
--
作者：
Seider TR;Gongvatana A;Woods AJ;Chen H;Porges EC;Cummings T;Correia S;Tashima K;Cohen RA
HIV疾病和老年都与脑白质的改变有关，通过液体衰减反转恢复(FLAIR)磁共振成像(MRI)上的白质高信号(WMH)和最近的扩散张量成像(DTI)来测量。这项研究调查了年龄和HIV血清状态对WMH和DTI测量的综合影响，以及这些白质测量之间的关系，其中88名HIV血清阳性(HIV+)和49名HIV-血清阴性(HIV-)年龄在23-79岁之间。使用半自动过程从FLAIR图像中量化WMH的全脑体积测量，同时计算使用基于轨迹的空间统计(TBSS)生成的全脑白质骨架的15个区域的分数各向异性(FA)。通过HIV相互作用发现的年龄表明，仅在HIV+参与者中，WMH和较高年龄之间存在显著关联。同样，与HIV参与者相比，HIV+患者的年龄显著增加，表明年龄较大与内囊后肢、大脑脚和前冠辐射区FA降低之间存在更强的相关性。就全脑WMH而言，艾滋病毒和年龄的交互作用比FA的任何一项指标都要强。在HIV+参与者中，较大的WMH和较低的前冠辐射FA与活动性丙型肝炎病毒感染、艾滋病病史和当前较高的CD4细胞计数相关。结果表明，年龄加剧了HIV相关的全脑WMH和额叶皮质下白质完整性的异常。
Both HIV disease and advanced age have been associated with alterations to cerebral white matter, as measured with white matter hyperintensities (WMH) on fluid attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI), and more recently with diffusion tensor imaging (DTI). This study investigates the combined effects of age and HIV serostatus on WMH and DTI measures, as well as the relationships between these white matter measures, in 88 HIV seropositive (HIV+) and 49 seronegative (HIV-) individuals aged 23–79 years. A whole-brain volumetric measure of WMH was quantified from FLAIR images using a semi-automated process, while fractional anisotropy (FA) was calculated for 15 regions of a whole-brain white matter skeleton generated using tract-based spatial statistics (TBSS). An age by HIV interaction was found indicating a significant association between WMH and older age in HIV+ participants only. Similarly, significant age by HIV interactions were found indicating stronger associations between older age and decreased FA in the posterior limbs of the internal capsules, cerebral peduncles, and anterior corona radiata in HIV+ vs. HIV- participants. The interactive effects of HIV and age were stronger with respect to whole-brain WMH than for any of the FA measures. Among HIV+ participants, greater WMH and lower anterior corona radiata FA were associated with active hepatitis C virus infection, a history of AIDS, and higher current CD4 cell count. Results indicate that age exacerbates HIV associated abnormalities of whole-brain WMH and fronto-subcortical white matter integrity.