T-Type Calcium Channel as a New Therapeutic Target for Tremor
T-Type Calcium Channel as a New Therapeutic Target for Tremor
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DOI：
10.1007/s12311-011-0277-y
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发表时间：
2011-09-01
期刊：
影响因子：
3.5
通讯作者：
Kondo, Tomoyoshi
中科院分区：
文献类型：
--
作者：
Miwa, Hideto;Kondo, Tomoyoshi
电压门控钙通道在许多生理和病理过程中发挥着重要作用。越来越多的研究表明，T型钙通道是治疗多种神经系统疾病的潜在靶点，例如癫痫、失眠和神经性疼痛。在这里，我们重点介绍了我们对 T 型钙通道调节及其对震颤疾病的影响的理解的最新进展。几种 T 型钙通道阻滞剂可有效抑制实验性震颤，这些震颤被认为源自小脑或基底神经节。在已应用于临床的T型钙通道阻滞剂中，唑尼沙胺的抗震颤功效引起了人们的关注。根据基础和临床研究，进入中枢神经系统的 T 型钙通道阻滞剂可能具有治疗震颤疾病的潜力。
Voltage-gated calcium channels play an important role in many physiological and pathological processes. Accumulating studies suggest that the T-type calcium channel is a potential target for the treatment of various neurological disorders, such as epilepsy, insomnia, and neuropathic pain. Here, we highlight recent advances in our understanding of T-type calcium channel regulation and their implications for tremor disorders. Several T-type calcium channel blockers effectively suppressed experimental tremors that have been suggested to originate from either the cerebellum or basal ganglia. Among T-type calcium channel blockers that have been used clinically, the anti-tremor efficacy of zonisamide garnered our attention. Based on both basic and clinical studies, the possibility is emerging that T-type calcium channel blockers that transit into the central nervous system may have therapeutic potentials for tremor disorders.