The influence of lack of reference conditions on dosimetry in pre-clinical radiotherapy with medium energy x-ray beams.
The influence of lack of reference conditions on dosimetry in pre-clinical radiotherapy with medium energy x-ray beams.
复制标题
缺乏参考条件对中能 X 射线束临床前放射治疗剂量测定的影响。
DOI：
10.1088/1361-6560/ab7b30
复制
发表时间：
2020
影响因子：
3.5
通讯作者：
Subiel A
中科院分区：
文献类型：
--
作者：
Subiel A
尽管在临床放射治疗中已经建立了完善的剂量测定法，但临床前和放射生物学研究中的剂量测量往往不足，从而破坏了已发表研究结果的可靠性和再现性。缺乏合适的剂量测定方案，加上临床前辐照平台的日益复杂，破坏了临床前研究的信心，并成为转化为临床实践的严重障碍。为了准确测量临床前放射治疗单元的输出，需要采用适当的中等能量X射线操作规范（CoP）。然而，水吸收剂量（DW）的确定依赖于使用空气中方法或在完全反向散射（即30× 30× 30 cm 3）条件下在参考深度2 cm处进行体模测量的反向散射因子（B w）的应用。这两种方法都需要至少30 cm厚的底层材料，这在典型的临床前辐照中从未实现。这项工作的重点是评价缺乏推荐的参考条件在剂量测量临床前设置的影响，旨在扩大目前的CoP的建议，以实际的实验条件，并强调缺乏正确的反向散射考虑放射生物学研究的潜在影响。
Despite well-established dosimetry in clinical radiotherapy, dose measurements in pre-clinical and radiobiology studies are frequently inadequate, thus undermining the reliability and reproducibility of published findings. The lack of suitable dosimetry protocols, coupled with the increasing complexity of pre-clinical irradiation platforms, undermines confidence in preclinical studies and represents a serious obstacle in the translation to clinical practice. To accurately measure output of a pre-clinical radiotherapy unit, appropriate Codes of Practice (CoP) for medium energy x-rays needs to be employed. However, determination of absorbed dose to water (D w) relies on application of backscatter factor (B w) employing in-air method or carrying out in-phantom measurement at the reference depth of 2 cm in a full backscatter (ie 30× 30× 30 cm 3) condition. Both of these methods require thickness of at least 30 cm of underlying material, which are never fulfilled in typical pre-clinical irradiations. This work is focused on evaluation the effects of the lack of recommended reference conditions in dosimetry measurements for pre-clinical settings and is aimed at extending the recommendations of the current CoP to practical experimental conditions and highlighting the potential impact of the lack of correct backscatter considerations on radiobiological studies.