Mortality Related to Severe Sepsis and Septic Shock Among Critically III Patients in Australia and New Zealand, 2000-2012
Mortality Related to Severe Sepsis and Septic Shock Among Critically III Patients in Australia and New Zealand, 2000-2012
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DOI：
10.1001/jama.2014.2637
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发表时间：
2014-04-02
影响因子：
120.7
通讯作者：
Bellomo, Rinaldo
中科院分区：
文献类型：
--
作者：
Kaukonen, Kirsi-Maija;Bailey, Michael;Bellomo, Rinaldo
严重脓毒症和脓毒性休克是重症监护病房（ICU）患者死亡的主要原因。目前尚不清楚是否在降低其死亡率方面取得了进展。目的描述重症监护病房患者中严重脓毒症伴和不伴休克的死亡率变化。2000年至2012年的观察性研究，包括来自澳大利亚和新西兰171个ICU的101 064例严重脓毒症患者，患者病例组合不同。结果严重脓毒症患者的绝对死亡率从35.0%（95%CI，33.2%~ 36.8%，949/2708）下降到18.4%（95%CI，17.8%~ 19.0%，2300/12512），死亡率从35.0%（95%CI，33.2%~ 36.8%，2300/12512）下降到18.4%（95%CI，17.8%~ 19.0%，2300/12512）。
IMPORTANCE Severe sepsis and septic shock are major causes of mortality in intensive care unit (ICU) patients. It is unknown whether progress has been made in decreasing their mortality rate.OBJECTIVE To describe changes in mortality for severe sepsis with and without shock in ICU patients.DESIGN, SETTING, AND PARTICIPANTS Retrospective, observational study from 2000 to 2012 including 101 064 patients with severe sepsis from 171 ICUs with various patient case mix in Australia and New Zealand.MAIN OUTCOMES AND MEASURES Hospital outcome (mortality and discharge to home, to other hospital, or to rehabilitation).RESULTS Absolute mortality in severe sepsis decreased from 35.0% (95% CI, 33.2%-36.8%; 949/2708) to 18.4% (95% CI, 17.8%-19.0%; 2300/12 512; P