Absolute quantification of brain metabolites by proton magnetic resonance spectroscopy in normal-appearing white matter of multiple sclerosis patients
Absolute quantification of brain metabolites by proton magnetic resonance spectroscopy in normal-appearing white matter of multiple sclerosis patients
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DOI：
10.1093/brain/122.3.513
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发表时间：
1999-03-01
期刊：
影响因子：
14.5
通讯作者：
Gallai, V
中科院分区：
文献类型：
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作者：
Sarchielli, P;Presciutti, O;Gallai, V
本研究的目的是通过H-1磁共振波谱技术获得一组多发性硬化症患者（27例复发缓解型和13例继发性进展型）正常白质中n -乙酰-天冬氨酸、胆碱、肌酸和磷酸肌酸水平的绝对定量。结果表明，多发性硬化症患者的额、顶叶白质中n -乙酰-天冬氨酸浓度明显低于对照组。这种减少在进行性患者中更为明显。正常脑白质n -乙酰-天冬氨酸浓度下降与扩展残疾状态和病变负荷显著相关，肌酸和胆碱浓度未见明显变化。这一发现与先前多发性硬化症病理过程的异质性一致，这种异质性不仅局限于病变，而且不仅涉及髓鞘，还涉及轴突，甚至在MRI上显示正常的白质中。
The aim of this research was to obtain an absolute quantification of the N-acetyl-aspartate, choline, creatine and phosphocreatine levels in normal-appearing white matter by means of H-1 magnetic resonance spectroscopy in a group of multiple sclerosis patients (27 with the relapsing-remitting form and 13 with the secondary progressive form). These values were compared with those of a group of 12 age-matched healthy control subjects, A significant decrease in the N-acetyl-aspartate concentration was found in normal-appearing white matter of frontal and parietal brain areas in multiple sclerosis patients compared with the same areas in control subjects. This reduction was more evident in progressive patients. The decrease in the N-acetyl-aspartate concentration in normal-appearing white matter significantly correlated with the Expanded Disability Status and the lesional load, No significant change was found in the concentration of creatine or choline. This finding concurs with previous evidence of heterogeneity in the multiple sclerosis pathological process which is not confined to the lesions and involves not only myelin, but also axons, even in white matter which appears normal on MRI.