Wnt5a and Wnt11 interact in a maternal Dkk1-regulated fashion to activate both canonical and non-canonical signaling in Xenopus axis formation
Wnt5a and Wnt11 interact in a maternal Dkk1-regulated fashion to activate both canonical and non-canonical signaling in Xenopus axis formation
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DOI：
10.1242/dev.029025
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发表时间：
2008-11-15
期刊：
影响因子：
4.6
通讯作者：
Heasman, Janet
中科院分区：
文献类型：
--
作者：
Cha, Sang-Wook;Tadjuidje, Emmanuel;Heasman, Janet
Wnt信号在发育和成人组织稳态中需要严格调控，以防止模式异常和肿瘤形成。在这里，我们发现母体Wnt拮抗剂Dkk1下调了非洲爪蟾胚胎正确建立轴所需的规范和非规范信号。我们发现Dkk活性的靶wnt是母体Wnt5a和Wnt11，这两种wnt对于规范和非规范信号传导都是必不可少的。我们确定Wnt5a和Wnt11形成了一个以前未被识别的复合体。这项工作提出了Wnt信号的一个新方面：两个Wnt在一个复合体中共同作用来调节胚胎模式。
Wnt signaling in development and adult tissue homeostasis requires tight regulation to prevent patterning abnormalities and tumor formation. Here, we show that the maternal Wnt antagonist Dkk1 downregulates both the canonical and non-canonical signaling that are required for the correct establishment of the axes of the Xenopus embryo. We find that the target Wnts of Dkk activity are maternal Wnt5a and Wnt11, and that both Wnts are essential for canonical and non-canonical signaling. We determine that Wnt5a and Wnt11 form a previously unrecognized complex. This work suggests a new aspect of Wnt signaling: two Wnts acting in a complex together to regulate embryonic patterning.