Depression and oxidative stress: results from a meta-analysis of observational studies.
Depression and oxidative stress: results from a meta-analysis of observational studies.
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DOI：
10.1097/psy.0000000000000009
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发表时间：
2014-01
影响因子：
3.3
通讯作者：
Szanton SL
中科院分区：
文献类型：
--
作者：
Palta P;Samuel LJ;Miller ER 3rd;Szanton SL
进行系统回顾和荟萃分析，定量测试和总结抑郁症导致氧化应激升高和抗氧化剂水平降低的假设。我们对报告抑郁症与氧化应激和/或抗氧化状态标志物之间关联的研究进行了荟萃分析。检索了 PubMed 和 EMBASE 数据库，查找从 1980 年 1 月到 2012 年 12 月发表的文章。采用按逆方差加权的随机效应模型，分别汇总氧化应激和抗氧化状态测量研究中的标准差 (Cohen’s d) 效应大小估计值。荟萃分析中纳入了 23 项研究，涉及 4980 名参与者。抑郁症最常使用《精神疾病诊断和统计手册》第四版标准来测量。研究发现，抑郁症与氧化应激之间的关联的科恩 d 效应大小为 0.55（95% 置信区间 = 0.47-0.63），表明与非抑郁症患者相比，抑郁症患者的氧化应激增加了约 0.55 个标准差 1 个标准差。研究结果显示出显着的异质性 (I2 = 80.0%, p < .001)。抑郁症和抗氧化状态标志物之间的关联也观察到了统计学上显着的影响（Cohen’s d = -0.24，95% 置信区间 = -0.33 至 -0.15）。这项荟萃分析在许多不同的研究中观察到抑郁症与氧化应激和抗氧化状态之间的关联。抑郁症测量值以及氧化应激标记物和抗氧化状态标记物的差异可以解释观察到的异质性。这些发现表明，抑郁症与不良健康结果之间的明确关联可能是由高氧化应激介导的。
To perform a systematic review and meta-analysis that quantitatively tests and summarizes the hypothesis that depression results in elevated oxidative stress and lower antioxidant levels. We performed a meta-analysis of studies that reported an association between depression and oxidative stress and/or antioxidant status markers. PubMed and EMBASE databases were searched for articles published from January 1980 through December 2012. A random-effects model, weighted by inverse variance, was performed to pool standard deviation (Cohen’s d) effect size estimates across studies for oxidative stress and antioxidant status measures, separately. Twenty-three studies with 4980 participants were included in the meta-analysis. Depression was most commonly measured using the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria. A Cohen’s d effect size of 0.55 (95% confidence interval = 0.47–0.63) was found for the association between depression and oxidative stress, indicating a roughly 0.55 of 1-standard-deviation increase in oxidative stress among individuals with depression compared with those without depression. The results of the studies displayed significant heterogeneity (I2 = 80.0%, p < .001). A statistically significant effect was also observed for the association between depression and antioxidant status markers (Cohen’s d = −0.24, 95% confidence interval = −0.33 to −0.15). This meta-analysis observed an association between depression and oxidative stress and antioxidant status across many different studies. Differences in measures of depression and markers of oxidative stress and antioxidant status markers could account for the observed heterogeneity. These findings suggest that well-established associations between depression and poor heath outcomes may be mediated by high oxidative stress.