Quantitative assessment of in vitro interactions implicates TATA-binding protein as a target of the VP16C transcriptional activation region.
Quantitative assessment of in vitro interactions implicates TATA-binding protein as a target of the VP16C transcriptional activation region.
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体外相互作用的定量评估表明 TATA 结合蛋白是 VP16C 转录激活区域的靶标。
DOI：
10.1016/j.abb.2004.03.002
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发表时间：
2004
影响因子：
3.9
通讯作者：
Triezenberg,StevenJ
中科院分区：
文献类型：
--
作者：
Nedialkov,YuriA;Triezenberg,StevenJ
Models of mechanisms of transcriptional activation in eukaryotes frequently invoke direct interactions of transcriptional activation domains with target proteins including general transcription factors or coactivators such as chromatin modifying complexes. The potent transcriptional activation domain (AD) of the VP16 protein of herpes simplex virus has previously been shown to interact with several general transcription factors including the TATA-binding protein (TBP), TBP-associated factor 9 (TAF9), TFIIA, and TFIIB. In surface plasmon resonance assays, a module of the VP16 AD designated VP16C (residues 452–490) bound to TBP with an affinity notably stronger than to TAF9, TFIIA or TFIIB. Moreover, the interaction of VP16C with TBP correlated well with transcriptional activity for a panel of VP16C substitution variants. These results support models in which the interactions of ADs with TBP play an important role in transcriptional activation.
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DOI：
10.1006/smvy.1993.1010
发表时间：
1993-06
期刊：
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DOI：
10.1016/s0021-9258(18)48334-2
发表时间：
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The Journal of biological chemistry
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