Mannich-Michael versus formal aza-Diels-Alder approaches to piperidine derivatives
Mannich-Michael versus formal aza-Diels-Alder approaches to piperidine derivatives
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DOI：
10.1039/c0ob00996b
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发表时间：
2011-01-01
影响因子：
3.2
通讯作者：
Whiting, Andrew
中科院分区：
文献类型：
--
作者：
Girling, P. Ricardo;Kiyoi, Takao;Whiting, Andrew
对氮杂-Diels-Alder反应的综述，主要集中在文献例子，这些文献例子是亚胺与富含电子的双烯或烯酮通过Lewis酸/Bronsted酸法或通过使用有机催化剂反应生成哌啶-4-酮。这篇综述质疑当使用含氧二烯时，氮杂-Diels-Alder反应的机理是否是分步进行的，而不是一致的。
A review into the aza-Diels-Alder reaction, mainly concentrating on literature examples that form piperidin-4-ones from the reaction of imines and electron rich dienes or enones, either through a Lewis acidic/Bronsted acid approach or through the use of an organocatalyst. This review questions whether the mechanism of the aza-Diels-Alder reaction is step wise as opposed to concerted when using oxygenated dienes.