Short- and long-term limbic abnormalities after experimental febrile seizures
Short- and long-term limbic abnormalities after experimental febrile seizures
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DOI：
10.1016/j.nbd.2008.07.010
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发表时间：
2008-11-01
影响因子：
6.1
通讯作者：
Hoogland, Govert
中科院分区：
文献类型：
--
作者：
Jansen, Jacobus F. A.;Lemmens, Evi M. P.;Hoogland, Govert
已知实验性热性癫痫（FS）可促进边缘系统的高兴奋性，并增加最终颞叶癫痫（TLE）的风险。伴随的显微结构和代谢变化的早期标记可以通过体内连续MRI提供。9日龄大鼠热疗诱导FS。在24小时和8周后，对FS大鼠和年龄匹配的对照组进行定量多模态MRI，包括海马体积和质子光谱，以及大脑T2弛豫和扩散张量成像（DTI）。9周时行组织学检查。海马T2松弛时间升高似乎是短暂的。杏仁核检测到的DTI异常持续了8周。海马的体积没有受到影响。组织学显示海马纤维密度和各向异性增加，杏仁核神经元表面积减少。定量序列MRI能够检测短暂的，最重要的是，长期fs引起的变化，反映微观结构的改变。(C) 2008爱思唯尔公司版权所有。
Experimental febrile seizures (FS) are known to promote hyperexcitability of the limbic system and increase the risk for eventual temporal lobe epilepsy (TLE). Early markers of accompanying microstructural and metabolic changes may be provided by in vivo serial MRI.FS were induced in 9-day old rats by hyperthermia. Quantitative multimodal MRI was applied 24 h and 8 weeks later, in rats with FS and age-matched controls, and comprised hippocampal volumetry and proton spectroscopy, and cerebral T2 relaxometry and diffusion tensor imaging (DTI). At 9 weeks histology was performed.Hippocampal T2 relaxation time elevations appeared to be transient. DTI abnormalities detected in the amygdala persisted up to 8 weeks. Hippocampal volumes were not affected. Histology showed increased fiber density and anisotropy in the hippocampus, and reduced neuronal surface area in the amygdala. Quantitative serial MRI is able to detect transient, and most importantly, long-term FS-induced changes that reflect microstructural alterations. (C) 2008 Elsevier Inc. All rights reserved.