Seasonality and shift in age-specific malaria prevalence and incidence in Binko and Carrière villages close to the lake in Selingué, Mali.
Seasonality and shift in age-specific malaria prevalence and incidence in Binko and Carrière villages close to the lake in Selingué, Mali.
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在马里塞林格湖附近的Binko和Carrière村庄的季节性和特定年龄的疟疾患病率和发病率的转变。
DOI：
10.1186/s12936-016-1251-4
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发表时间：
2016-04-18
期刊：
影响因子：
3
通讯作者：
Doumbia S
中科院分区：
文献类型：
--
作者：
Touré M;Sanogo D;Dembele S;Diawara SI;Oppfeldt K;Schiøler KL;Haidara DB;Traoré SF;Alifrangis M;Konradsen F;Doumbia S
疟疾在马里的传播是季节性的，在10月雨季结束时达到高峰。这项研究评估了塞林格两个村庄10岁以下儿童疟疾流行病学的季节性变化：位于Sankarani河沿着但远离水电站大坝的Carrière和靠近水电站大坝的灌溉稻田附近的Binko。这项研究的目的是提供位于塞林格湖附近的两个地点疟疾发病率的基线数据、季节模式和年龄分布。在地理上，Selingué地区位于Sakanrani盆地，属于马里第三行政区Sikasso的Yanfolila区。2010年10月（传播季节结束）和2011年7月（传播季节开始）进行了两次横断面调查，以确定儿童中无症状寄生虫病和贫血的点流行率。通过2010年11月至2011年10月的主动和被动病例检测，确定了549名儿童的每月累积疟疾发病率。每年的临床发作次数在队列中的儿童中确定。Logistic回归用于确定疟疾的危险因素。疟疾寄生虫病的流行率在卡里埃（2010年10月和2011年7月分别为52.0- 18.9%）和宾科（2010年10月和2011年7月分别为29.8- 23.8%）季节性很强的村庄之间差异很大。6-9岁的儿童携带寄生虫的可能性至少是5岁以下儿童的两倍。就疟疾发病率而言，宾科和卡里埃的所有儿童中分别有64.8- 71.9%至少经历过一次临床疟疾发作。8月至10月（雨季结束）为发病高峰期，但发病率一直高到12月。令人惊讶的是，5-9岁儿童患临床疟疾的风险比更年幼的儿童高2 - 9倍。临床发病高峰从5-9岁儿童转移，这要求扩大控制干预措施，如针对传播高峰月份的季节性疟疾化学预防。
Malaria transmission in Mali is seasonal and peaks at the end of the rainy season in October. This study assessed the seasonal variations in the epidemiology of malaria among children under 10 years of age living in two villages in Selingué: Carrière, located along the Sankarani River but distant from the hydroelectric dam, and Binko, near irrigated rice fields, close to the dam. The aim of this study was to provide baseline data, seasonal pattern and age distribution of malaria incidence in two sites situated close to a lake in Selingué. Geographically, Selingué area is located in the basin of Sakanrani and belongs to the district of Yanfolila in the third administrative region of Mali, Sikasso. Two cross-sectional surveys were conducted in October 2010 (end of transmission season) and in July 2011 (beginning of transmission season) to determine the point prevalence of asymptomatic parasitaemia, and anaemia among the children. Cumulative incidence of malaria per month was determined in a cohort of 549 children through active and passive case detection from November 2010 through October 2011. The number of clinical episodes per year was determined among the children in the cohort. Logistic regression was used to determine risk factors for malaria. The prevalence of malaria parasitaemia varied significantly between villages with a strong seasonality in Carrière (52.0–18.9 % in October 2010 and July 2011, respectively) compared with Binko (29.8–23.8 % in October 2010 and July 2011, respectively). Children 6–9 years old were at least twice more likely to carry parasites than children up to 5 years old. For malaria incidence, 64.8–71.9 % of all children experienced at least one episode of clinical malaria in Binko and Carrière, respectively. The peak incidence was observed between August and October (end of the rainy season), but the incidence remained high until December. Surprisingly, the risk of clinical malaria was two- to nine-fold higher among children 5–9 years old compared to younger children. A shift in the peak of clinical episodes from children under 5–9 years of age calls for expanding control interventions, such as seasonal malaria chemoprophylaxis targeting the peak transmission months.