Substrate activation of cell adhesion factor as a prerequisite for cell attachment
Substrate activation of cell adhesion factor as a prerequisite for cell attachment
复制标题
细胞粘附因子的底物激活是细胞附着的先决条件
DOI：
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发表时间：
1978
影响因子：
6.4
通讯作者：
E. Pearlstein
中科院分区：
文献类型：
--
作者：
E. Pearlstein
Cell Adhesion Factor, complexed to insoluble collagen‐coated tissue culture dishes, is required for the attachment of fibroblasts to this substrate. In solution, the factor has no demonstrable affinity for cells in suspension following trypsin‐EDTA removal of cells from monolayer. Cell surface receptors for the factor are present during the assay period since cells allowed to recover for 1 h at 37° C, 4° C or in the presence of 10−6 M cyclo‐heximide show exactly the same kinetics of adhesion as control cells. It is demonstrated that Cell Adhesion Factor acquires affinity for the cell surface only following its binding to collagen.
