Luteolin, a food-derived flavonoid, suppresses adipocyte-dependent activation of macrophages by inhibiting JNK activation
Luteolin, a food-derived flavonoid, suppresses adipocyte-dependent activation of macrophages by inhibiting JNK activation
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DOI：
10.1016/j.febslet.2009.10.045
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发表时间：
2009-11-19
期刊：
影响因子：
3.5
通讯作者：
Kawada, Teruo
中科院分区：
文献类型：
--
作者：
Ando, Chieko;Takahashi, Nobuyuki;Kawada, Teruo
脂肪细胞和巨噬细胞之间的相互作用有助于肥胖脂肪组织中胰岛素抵抗的发展。在这项研究中，我们研究了木樨草素，食物来源的黄酮类化合物，是否可以抑制脂肪细胞和巨噬细胞之间相互作用的炎症介质的产生。使用脂肪细胞和巨噬细胞共培养系统的实验表明，毛地黄黄酮抑制炎症介质的产生。此外，激活的巨噬细胞是木犀草素抑制作用的靶点。木犀草素可抑制JNK的磷酸化，抑制活化巨噬细胞中炎症介质的产生。结果表明，毛地黄黄酮可抑制脂肪细胞和巨噬细胞之间的相互作用，从而抑制炎症介质的产生，提示毛地黄黄酮是一种有价值的治疗代谢综合征的食物源性化合物。(C)2009年欧洲生物化学学会联合会。由Elsevier B出版。版权所有© 2016
Interaction between adipocytes and macrophages contributes to the development of insulin resistance in obese adipose tissues. In this study, we examined whether luteolin, food-derived flavonoid, could suppress the production of inflammatory mediators of the interaction between adipocytes and macrophages. Experiments using a coculture system of adipocytes and macrophages showed that luteolin suppressed the production of inflammatory mediators. In addition, activated macrophages were targets for the suppressive effect of luteolin. Luteolin inhibited the phosphorylation of JNK and suppressed the production of inflammatory mediators in the activated macrophages. The findings indicate that luteolin can inhibit the interaction between adipocytes and macrophages to suppress the production of inflammatory mediators, suggesting that luteolin is a valuable food-derived compound for the treatment of metabolic syndrome. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.