STRUCTURE, DIVERSITY AND SYNAPTIC LOCALIZATION OF INHIBITORY GLYCINE RECEPTORS
STRUCTURE, DIVERSITY AND SYNAPTIC LOCALIZATION OF INHIBITORY GLYCINE RECEPTORS
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DOI：
10.1016/0928-4257(94)90087-6
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发表时间：
1994-01-01
影响因子：
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通讯作者：
RAMMING, M
中科院分区：
文献类型：
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作者：
BETZ, H;KUHSE, J;RAMMING, M
抑制性甘氨酸受体（GlyR）介导脊椎动物中枢神经系统的脊髓、脑干和其他区域中的突触后抑制。生物化学和分子生物学的方法已经确定了不同的发育和区域调节的GlyR异构体，导致至少四个基因的差异表达的配体结合α亚基的不同变体的编码。分子研究已经允许鉴定参与配体结合、通道形成和受体组装的GlyR亚基结构域。在突触后膜，GlyR与93 kDa微管蛋白结合的外周膜蛋白，桥蛋白共定位。桥蛋白表达的反义抑制防止GlyR在突触后膜特化的积累。因此，桥蛋白是突触后受体拓扑结构所必需的。
The inhibitory glycine receptor (GlyR) mediates postsynaptic inhibition in spinal cord, brain stem and other regions of the vertebrate central nervous system. Biochemical and molecular approaches have identified different developmentally and regionally regulated GlyR isoforms that result from the differential expression of at least four genes coding for different variants of the ligand-binding alpha subunit. Molecular studies have allowed identification of GlyR subunit domains implicated in ligand binding, channel formation and receptor assembly. At the postsynaptic membrane, the GlyR colocalizes with a 93-kDa tubulin-binding peripheral membrane protein, gephyrin. Antisense inhibition of gephyrin expression prevents GlyR accumulation at postsynaptic membrane specialization. Thus, gephyrin is essential for postsynaptic receptor topology.