FGF‐23 is associated with cardiac troponin T and mortality in hemodialysis patients
FGF‐23 is associated with cardiac troponin T and mortality in hemodialysis patients
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FGF-23 与血液透析患者的心肌肌钙蛋白 T 和死亡率相关
DOI：
10.1111/j.1542-4758.2011.00630.x
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发表时间：
2011
影响因子：
1.3
通讯作者：
R. Foley
中科院分区：
文献类型：
--
作者：
R. Holden;David Beseau;S. Booth;Michael A. Adams;J. Garland;R. Morton;C. Collier;R. Foley
成纤维细胞生长因子23 （FGF‐23）在终末期肾病患者中升高，与死亡率、血管钙化、骨转换标志物和左心室肥厚有关。在这项队列研究中，我们确定了FGF‐23（包括心肌肌钙蛋白T [cTNT]）的相关性，并确定了其与103例流行血液透析患者3.5年随访期间死亡率的关系。平均年龄为61.2岁（15.5岁），平均透析年龄为4.19岁（4.6岁）。FGF‐23的中位数（四分位数范围）为1259 (491,2885)RU/mL。对数转化FGF - 23浓度的独立预测因子（估计标准误差）包括磷（0.75 [0.237],P = 0.002）和心肌肌钙蛋白T （1.04 [0.41], P = 0.01）。共有57人死亡。在完全调整的模型中，死亡率的重要预测因子包括年龄和白蛋白。FGF - 23与cTNT之间的独立关联是一个新发现。这种关系是否支持磷酸化稳态失调的下游效应可能会增强心脏重塑的可能性，需要进一步研究。
Fibroblast growth factor 23 (FGF‐23) is elevated in patients with end‐stage kidney disease and has been linked with mortality, vascular calcification, markers of bone turnover, and left ventricular hypertrophy. In this cohort study, we determined the correlates of FGF‐23 (including cardiac troponin T [cTNT]) and determined its association with mortality over 3.5 years of follow‐up in 103 prevalent hemodialysis patients. Mean age was 61.2 (15.5) and the mean dialysis vintage was 4.19 years (4.6). The median (interquartile range) FGF‐23 was 1259 (491, 2885) RU/mL. Independent predictors (estimate standard error) of log‐transformed FGF‐23 concentrations included phosphorus (0.75 [0.237], P = 0.002) and cardiac troponin T (1.04 [0.41], P = 0.01). There were 57 deaths. In the fully adjusted model, the significant predictors of mortality included age and albumin. The independent association between FGF‐23 and cTNT is a novel finding. Whether this relationship supports the possibility that a downstream effect of dysregulated phosphorous homeostasis may be enhanced cardiac remodeling requires further study.
影响因子：
20.1
作者：
S. Vatner
通讯作者：
S. Vatner
影响因子：
13.6
作者：
Slinin, Y;Foley, RN;Collins, AJ
通讯作者：
Collins, AJ
影响因子：
13.6
作者：
Gutierrez, O;Isakova, T;Wolf, M
通讯作者：
Wolf, M