Motivation and organizational principles for anatomical knowledge representation: The digital anatomist symbolic Knowledge base
Motivation and organizational principles for anatomical knowledge representation: The digital anatomist symbolic Knowledge base
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DOI：
10.1136/jamia.1998.0050017
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发表时间：
1998-01-01
影响因子：
6.4
通讯作者：
Brinkley, JF
中科院分区：
文献类型：
--
作者：
Rosse, C;Mejino, JL;Brinkley, JF
目的：在组织的宏观层面上，将构成人体的物理对象和空间概念化，指定为机器可解析的本体，以人类可读的形式，对于解剖信息的专家和新手用户都是可以理解的。设计：作为UMLS语义网络和元词库的解剖增强，通过基于物理解剖实体的划分和空间关系来指定物理解剖实体的类和子类的定义属性和差异来制定解剖本体。分类的有效性进行了评估，通过实例化的本体的胸部。几个传递关系被用于象征性地建模方面的物理organizationofthorac.Results：通过宣布器官作为身体的宏观组织单元，并定义的实体，构成器官和更高层次的实体构成的器官，所有的解剖实体可以被分配到三个顶级类（解剖结构，解剖空间实体和身体物质）之一。本体容纳系统和区域（地形）的解剖学观点，以及不同的临床命名惯例的解剖entities.Conclusions：本体制定的胸部是可扩展到微观和细胞水平，以及其他身体部位，在它的类subUNK基本上所有的解剖实体，构成身体。这些实体及其关系的明确定义提供了解剖概念表示标准的第一个要求。从解剖学的角度来构思，本体可以被概括和映射到其他生物医学领域和需要解剖学知识的问题解决任务。
Objective: Conceptualization of the physical objects and spaces that constitute the human body at the macroscopic level of organization specified as a machine-parseable ontology that, in its human-readable form, is comprehensible to both expert and novice users of anatomical information.Design: Conceived as an anatomical enhancement of the UMLS Semantic Network and Metathesaurus, the anatomical ontology was formulated by specifying defining attributes and differentia for classes and subclasses of physical anatomical entities based on their partitive and spatial relationships. The validity of the classification was assessed by instantiating the ontology for the thorax. Several transitive relationships were used for symbolically modeling aspects of the physical organization of the thorax.Results: By declaring Organ as the macroscopic organizational unit of the body, and defining the entities that constitute organs and higher level entities constituted by organs, all anatomical entities could be assigned to one of three top level classes (Anatomical structure, Anatomical spatial entity and Body substance). The ontology accommodates both the systemic and regional (topographical) views of anatomy, as well as diverse clinical naming conventions of anatomical entities.Conclusions: The ontology formulated for the thorax is extendible to microscopic and cellular levels, as well as to other body parts, in that its classes subsume essentially all anatomical entities that constitute the body. Explicit definitions of these entities and their relationships provide the first requirement for standards in anatomical concept representation. Conceived from an anatomical viewpoint, The ontology can be generalized and mapped to other biomedical domains and problem solving tasks that require anatomical knowledge.