Short term effects of rilmenidine on left ventricular hypertrophy and systolic and diastolic function in patients with essential hypertension - Comparison with an angiotensin converting enzyme inhibitor and a calcium antagonist
Short term effects of rilmenidine on left ventricular hypertrophy and systolic and diastolic function in patients with essential hypertension - Comparison with an angiotensin converting enzyme inhibitor and a calcium antagonist
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DOI：
10.1536/jhj.44.693
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发表时间：
2003-09-01
期刊：
影响因子：
--
通讯作者：
Ikitimur, B
中科院分区：
文献类型：
--
作者：
Koldas, L;Ayan, F;Ikitimur, B
本文观察了利美尼定对高血压所致左室肥厚（LVH）及左室收缩和舒张功能的短期（3个月）作用，并与培哚普利和硝苯地平缓释剂进行了比较。60例患者（男39例，女21例），平均年龄59 ± 14岁，有轻度至中度全身动脉高压，随机分为3组。第一组接受1毫克/天的利美尼定，第二组4毫克/天的培哚普利，和第三组20毫克/天的硝苯地平SR。所有的药物诱导相似的收缩压和舒张压（BP）值的下降。左心室质量（LVM）和LVM指数在所有组中均降低，并与E/A比值显著增加相关。第1组和第2组的左心室质量降低与平均动脉压降低（左心室质量/毫米汞柱）之间的比值较高。左室质量与左室质量指数E/A、dv/dt呈负相关。利美尼定不改变血液化学和血脂谱值，尽管利美尼定对血脂谱和生化参数的作用是中性的，但在控制高血压和减轻左心室肥厚方面，利美尼定与培哚普利和硝苯地平一样有效。
The short term (three months) effects of rilmenidine on systemic hypertension induced left ventricular hypertrophy (LVH) and left ventricular systolic and diastolic functions ill comparison with those of perindopril and nifedipine-slow release (SR) formulation were studied. The short term effects of rilmenidine oil biochemical parameters and lipid profiles were evaluated.Sixty patients (39 men, 21 women) with a mean age of 59 +/- 14 years and with mild to moderate systemic arterial hypertension were enrolled in three groups. The first group received I mg/day of rilmenidine, the second group 4 mg/day of perindopril, and the third group 20 mg/day of nifedipine SR. All drugs induced a similar decrease in systolic and diastolic blood pressure (BP) values. Left ventricular mass (LVM) and LVM index decreased equally in all groups associated with a significant increase in the E/A ratio. The ratio between the reduction in LVM and decrease ill mean arterial pressure (LVM/mmHG) was higher in groups 1 and 2. Negative correlations between LVM and LVMI E/A, and the dv/dt ratio were obtained. Rilmenidine did not change the blood chemistry and lipid profile values.Despite its neutral effect on lipid profile and biochemical parameters, rilmenidine is as effective as perindopril and nifedipine in controlling hypertension and decreasing left ventricular hypertrophy.