Prognostic evaluation of microRNA-210 in various carcinomas: Evidence from 19 studies.
Prognostic evaluation of microRNA-210 in various carcinomas: Evidence from 19 studies.
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DOI：
10.1097/md.0000000000008113
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发表时间：
2017-10
期刊：
影响因子：
1.6
通讯作者：
Qin C
中科院分区：
文献类型：
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作者：
Liu Y;Wang Y;Xu Q;Zhou X;Qin Z;Chen C;Zhang Q;Tian Y;Zhang C;Li X;Qin C
我们进行了这项荟萃分析，以全面评估MicroRNA-210（miR-210）表达对癌症总生存率（OS）的作用。我们在PubMed、EMBASE、科克伦图书馆和Science Direct数据库中检索了截至2016年11月1日关于miR-210和癌症的相关文献。我们计算了OS的合并风险比（HR）和95%置信区间（CI），比较了现有研究患者中miR-210的高表达和低表达水平。进行亚组分析以评估miR-210在种族和癌症类型中的特定作用。使用Begg漏斗图和Egger回归检验评估发表偏倚。总体而言，本荟萃分析涉及19项研究。结果表明，上调的miR-210可能与各种癌症中的OS结局较差相关，合并HR为1.80（95%CI：1.29-2.51）。当按疾病分层时，在乳腺癌（HR = 2.67，95% CI：1.24-5.76）和胶质瘤（HR = 2.42，95% CI：1.32-4.43）中检测到显著结果。 此外，在按种族进行的亚组分析中，仅在亚洲人群中检测到显著结果（HR = 2.14，95% CI：1.37-3.34）。 目前的荟萃分析表明，高表达的miR-210与癌症患者的OS显着相关，它有可能成为癌症的预后标志物。
We performed this meta-analysis to provide a comprehensive evaluation of the role of MicroRNA-210 (miR-210) expression on the overall survival (OS) rate of cancers. We searched for relevant available literatures on miR-210 and cancer until November 1st, 2016 on the databases PubMed, EMBASE, Cochrane Library, and Science Direct database. We calculated the pooled hazard ratio (HR) with 95% confidence intervals (CIs) for OS, which compared the high and low expression levels of miR-210 in patients of the available studies. Subgroup analysis was performed to evaluate the specific role of miR-210 in ethnicity and the type of cancers. Publication bias was evaluated using Begg funnel plots and Egger regression test. Overall, 19 studies were involved in this meta-analysis. The result indicated that upregulated miR-210 might be associated with poor OS outcome in various carcinomas, with the pooled HR of 1.80 (95% CI: 1.29–2.51). When stratified by disease, significant results were detected in breast cancer (HR = 2.67, 95% CI: 1.24–5.76) and glioma (HR = 2.42, 95% CI: 1.32–4.43). Besides, in the subgroup analysis by ethnicity, significant results were detected only in Asian populations (HR = 2.14, 95% CI: 1.37–3.34). The present meta-analysis suggests that high expressed miR-210 is significantly associated with OS in cancer patients, which has the potential to be a prognostic marker in cancers.