Toward novel vaccines and therapies based on negative-strand RNA viruses.
Toward novel vaccines and therapies based on negative-strand RNA viruses.
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开发基于负链 RNA 病毒的新型疫苗和疗法。
DOI：
10.1007/978-3-662-06099-5_8
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发表时间：
2004
影响因子：
--
通讯作者：
Cattaneo,R
中科院分区：
文献类型：
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作者：
vonMessling,V;Cattaneo,R
对负链RNA病毒的研究提出了产生更多减毒病毒的新策略。反向遗传学使这些战略得以实施，目前正在研制新的或改进的单价疫苗。此外，已经生产了表达外源蛋白或表位的重组病毒，目的是开发能够刺激针对一种以上病原体的体液和细胞免疫反应的多价疫苗。最后，重组病毒选择性地进入表达肿瘤标记物或HIV包膜蛋白的细胞，并被证明可以裂解
The study of negative-strand RNA viruses has suggested new strategies to produce more attenuated viruses. Reverse genetics has allowed the implementation of the strategies, and new or improved monovalent vaccines are being developed. In addition, recombinant viruses expressing foreign proteins or epitopes have been produced with the aim of developing multivalent vaccines capable of stimulating humoral and cellular immune responses against more than one pathogen. Finally, recombinant viruses that selectively enter cells expressing tumor markers or the HIV envelope protein have been engineered and shown to lyse