Neural crest migration: trailblazing ahead.
Neural crest migration: trailblazing ahead.
复制标题
神经rest迁移：开拓前方。
DOI：
10.12703/p7-02
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
McLennan R
中科院分区：
文献类型：
--
作者：
Kulesa PM;McLennan R
在脊椎动物体内，胚胎细胞迁移模式在细胞的时间和空间分布上极其复杂。然而，体内可视化、细胞检测和计算建模方面的进展正在提取这些模式机制本质所依据的关键特征。本综述的重点强调了在胚胎发育过程中对高度侵袭性的神经嵴细胞及其迁移模式研究的最新进展。我们在三个主要主题内讨论这些进展，并包括对已出现的计算模型的描述，这些模型旨在更快速地整合和测试神经嵴迁移的假设机制。我们以有望揭示新见解并有助于将结果转化为与人类神经嵴相关的出生缺陷和转移性癌症的技术进展作为结论。
Embryonic cell migration patterns are amazingly complex in the timing and spatial distribution of cells throughout the vertebrate landscape. However, advances in in vivo visualization, cell interrogation, and computational modeling are extracting critical features that underlie the mechanistic nature of these patterns. The focus of this review highlights recent advances in the study of the highly invasive neural crest cells and their migratory patterns during embryonic development. We discuss these advances within three major themes and include a description of computational models that have emerged to more rapidly integrate and test hypothetical mechanisms of neural crest migration. We conclude with technological advances that promise to reveal new insights and help translate results to human neural crest-related birth defects and metastatic cancer.