OBSTETRIC COMPLICATIONS AS ANTECEDENTS OF SCHIZOPHRENIA - EMPIRICAL EFFECTS OF USING DIFFERENT OBSTETRIC COMPLICATION SCALES
OBSTETRIC COMPLICATIONS AS ANTECEDENTS OF SCHIZOPHRENIA - EMPIRICAL EFFECTS OF USING DIFFERENT OBSTETRIC COMPLICATION SCALES
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DOI：
10.1016/0022-3956(94)90042-6
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发表时间：
1994-11-01
影响因子：
4.8
通讯作者：
SJOSTROM, K
中科院分区：
文献类型：
--
作者：
MCNEIL, TF;CANTORGRAAE, E;SJOSTROM, K
新的McNeil-Sjostrom产科并发症量表（OCs），以及Lewis等人的量表（精神分裂症：科学进展）。牛津大学出版社，1989)和Parnas等人（英国精神病学杂志，140,416-420,1982），采用盲目评估的医院妊娠和出生记录信息，对来自同一医院分娩系列的70名单胎精神分裂症患者和70名人口统计学匹配的对照组的OC史进行了研究。通过McNeil-Sjostrom量表，我们发现精神分裂症患者在整个生殖过程中，分娩和新生儿时期的OCs发生率显著增加，但在怀孕期间则没有。这些精神分裂症患者的OCs在Lewis等人量表的评分中也有显著增加，但在Parnas等人量表中没有发现。将这三种量表进一步应用于通过父母报告获得的23对精神分裂症不一致和10对精神分裂症一致的同卵双胞胎（MZ）以及7对正常对照MZ对的OC数据，当使用McNeil-Sjostrom和Parnas等人的量表评估时，发现不同双胞胎组的OC率存在显著差异，而Lewis等人的量表则没有。因此，研究中使用的特定评分系统不仅对精神分裂症患者与对照组的OC病史的研究结果非常重要，而且对精神分裂症中OC与其他假定的病因之间的关系也非常重要。三种量表中，McNeil-Sjostrom量表对精神分裂症患者的OC史评价最为敏感。
The new McNeil-Sjostrom Scale for obstetric complications (OCs), as well as scales of Lewis et al. (Schizoprenia: Scientific progress. Oxford University Press, 1989) and Parnas et al. (British Journal of Psychiatry, 140, 416-420, 1982), were applied to the OC histories of 70 singleton schizophrenics and 70 demographically-matched controls from the same hospital delivery series, using blindly assessed hospital pregnancy and birth record information. With the McNeil-Sjostrom scale, schizophrenics were found to have significantly increased rates of OCs for the total reproduction, as well as for labor-delivery and the neonatal period but not for pregnancy. Significant increases in OCs in these schizophrenics were also found in scores produced by the Lewis et al. scale but not by the Parnas et al. scale. Further application of these three scales to OC data obtained through parental report for 23 monozygotic (MZ) twin pairs discordant and 10 pairs concordant for schizophrenia, as well as seven normal control MZ pairs, showed a significant difference in OC rates across the different twin pair groups, when assessed by the McNeil-Sjostrom and Parnas et al. scales, but not by the Lewis et al. scale. The particular scoring system used in a study is thus of considerable importance not only for findings concerning OC histories of schizophrenics vs. controls, but also For the relationship between OCs and other presumed etiological factors in schizophrenia. Among the three scales, the McNeil-Sjostrom scale provided the most sensitive assessment of OC history for schizophrenics.