Defective CD8 T cell memory following acute infection without CD4 T cell help
Defective CD8 T cell memory following acute infection without CD4 T cell help
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DOI：
10.1126/science.1083317
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发表时间：
2003-04-11
期刊：
影响因子：
56.9
通讯作者：
Bevan, MJ
中科院分区：
文献类型：
--
作者：
Sun, JC;Bevan, MJ
CD8(+)细胞毒性T细胞对病原体的反应被认为是CD4(+)辅助T细胞独立的，因为感染因子提供自己的炎症信号。缺乏CD4(+) T细胞的小鼠对单核细胞增生李斯特氏菌产生与野生型小鼠相同的初级CD8反应，并迅速清除感染。然而，以前的动物对挑战的保护性记忆逐渐丧失。正常小鼠的记忆CD8+T细胞可以快速反应，但在没有CD4帮助的情况下产生的记忆CD8+T细胞在对抗原二次遭遇的反应能力上存在缺陷。结果强调了 CD4 在促进保护性 CD8 记忆发育方面的先前未描述的作用。
The CD8(+) cytotoxic T cell response to pathogens is thought to be CD4(+) helper T cell independent because infectious agents provide their own inflammatory signals. Mice that lack CD4(+) T cells mount a primary CD8 response to Listeria monocytogenes equal to that of wild-type mice and rapidly clear the infection. However, protective memory to a challenge is gradually lost in the former animals. Memory CD8(+) T cells from normal mice can respond rapidly, but memory CD8(+) T cells that are generated without CD4 help are defective in their ability to respond to secondary encounters with antigen. The results highlight a previously undescribed role for CD4 help in promoting protective CD8 memory development.