Endocrinological markers for assessment of hyperandrogenemia in hirsute women
Endocrinological markers for assessment of hyperandrogenemia in hirsute women
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DOI：
10.1159/000096036
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发表时间：
2007-01-01
期刊：
影响因子：
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通讯作者：
Dittrich, Ralf
中科院分区：
文献类型：
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作者：
Mueller, Andreas;Cupisti, Susanne;Dittrich, Ralf
背景资料：将多毛症女性的内分泌学参数（总睾酮[TT]、游离睾酮[FT]、双氢睾酮[DHT]、硫酸脱氢表雄酮[DHEAS]和性激素结合球蛋白[SHBG]）和计算参数（计算FT（cFT）、计算生物可利用睾酮（cBT）和游离雄激素指数[FAI]）与对照组的值进行比较。问题仍然是，cFT或cBT是否是更合适的标记物，用于评估高雄激素血症在临床情况下，如多毛症的妇女。研究方法：66名妇女的改良Ferriman-Gallwey（mF-G）评分>= 6分，被归类为多毛症组，58名妇女的mF-G评分为
Background: Measured endocrinological parameters (total testosterone [TT], free testosterone [FT], dihydrotestosterone [DHT], dehydroepiandrosterone sulfate [DHEAS], and sex hormone binding globulin [SHBG]) and calculated parameters (calculated FT (cFT), calculated bioavailable testosterone (cBT), and the free androgen index [FAI]) in women with hirsutism were compared to the values of a control group. The question remains if cFT or cBT are more appropriate markers for assessment of hyperandrogenemia in clinical situations such as hirsutism in women. Methods: Sixty-six women showed an modified Ferriman-Gallwey (mF-G) score of >= 6 and were classified as hirsutism group and 58 women showed mF-G scores of