Use of a compact pixellated gamma camera for small animal pinhole SPECT imaging
Use of a compact pixellated gamma camera for small animal pinhole SPECT imaging
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DOI：
10.1007/bf03027376
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发表时间：
2006-07
影响因子：
2.6
通讯作者：
T. Zeniya;H. Watabe;T. Aoi;K. Min Kim;N. Teramoto;T. Takeno;Y. Ohta;Takuya Hayashi;H. Mashino;Toshihiro Ota;S. Yamamoto;H. Iida
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文献类型：
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作者：
T. Zeniya;H. Watabe;T. Aoi;K. Min Kim;N. Teramoto;T. Takeno;Y. Ohta;Takuya Hayashi;H. Mashino;Toshihiro Ota;S. Yamamoto;H. Iida
针孔SPECT能在活体内对小动物的生理功能进行高分辨率三维成像，有助于在临床前试验中对药物开发和再生治疗进行客观评估。对于轻便性和移动性，微型尺寸的SPECT系统是有用的。我们开发了一个小动物SPECT系统的基础上，一个紧凑的高分辨率伽马相机安装到针孔准直器和对象旋转单元。方法γ照相机由22 × 22像素的1.8mm × 1.8mm × 5 mm的NaI（TI）晶体组成，晶体间距为0.2mm，与64通道的2″平板位置敏感光电倍增管（Hamamatsu H8500）耦合。摄像机的有效成像区域为43.8 mm × 43.8 mm。数据采集由个人计算机（Microsoft Windows）通过摄像机控制器控制。通过与旋转单元同步，获得SPECT图像的360°以上投影数据。由钨制成的刀口针孔准直器连接在相机上，具有0.5 mm和1.0 mm的孔径。用~（99）mTc和~（201）T_1溶液评价了系统的基本性能。测量了能量分辨率、系统空间分辨率和计数率线性度。静脉注射~（201）T1 C1后，依次进行大鼠心肌SPECT显像。投影数据重建使用以前验证的针孔3D-OSEM method.ResultsThe能量分辨率在140 keV是14.8%，使用点源。系统的空间分辨率分别为2.8-mm的FWHM和2.5-mm的FWHM为99 mTc和201 T1线源，分别在30-mm的源距离（放大倍数为1.3），使用1.0-mm的针孔。在10 kcps以下，活性与计数率呈良好的线性关系。在大鼠的研究中，左心室壁清晰可见，在所有scans.ConclusionsWe开发了一个紧凑的SPECT系统，使用紧凑型伽玛相机的小动物和评估的基本物理性能。本系统可用于小动物的生物功能如心肌血流量的定量。
ObjectivesPinhole SPECT which permitsin vivohigh resolution 3D imaging of physiological functions in small animals facilitates objective assessment of pharmaceutical development and regenerative therapy in pre-clinical trials. For handiness and mobility, the miniature size of the SPECT system is useful. We developed a small animal SPECT system based on a compact high-resolution gamma camera fitted to a pinhole collimator and an object-rotating unit. This study was aimed at evaluating the basic performance of the detection system and the feasibility of small animal SPECT imaging.MethodsThe gamma camera consists of a 22 × 22 pixellated scintillator array of 1.8 mm × 1.8 mm × 5 mm NaI(TI) crystals with 0.2-mm gap between the crystals coupled to a 2″ flat panel position-sensitive photomultiplier tube (Hamamatsu H8500) with 64 channels. The active imaging region of the camera was 43.8 mm × 43.8 mm. Data acquisition is controlled by a personal computer (Microsoft Windows) through the camera controller. Projection data over 360° for SPECT images are obtained by synchronizing with the rotating unit. The knife-edge pinhole collimators made of tungsten are attached on the camera and have 0.5-mm and 1.0-mm apertures. The basic performance of the detection system was evaluated with99mTc and201T1 solutions. Energy resolution, system spatial resolution and linearity of count rate were measured. Rat myocardial perfusion SPECT scans were sequentially performed following intravenous injection of201T1C1. Projection data were reconstructed using a previously validated pinhole 3D-OSEM method.ResultsThe energy resolution at 140 keV was 14.8% using a point source. The system spatial resolutions were 2.8-mm FWHM and 2.5-mm FWHM for99mTc and201T1 line sources, respectively, at 30-mm source distance (magnification factor of 1.3) using a 1.0-mm pinhole. The linearity between the activity and count rate was good up to 10 kcps. In a rat study, the left ventricular walls were clearly visible in all scans.ConclusionsWe developed a compact SPECT system using compact gamma camera for small animals and evaluated basic physical performances. The present system may be of use for quantitation of biological functions such as myocardial blood flow in small animals.