Different immune functions of peripheral blood, regional lymph node, and tumor infiltrating lymphocytes in lung cancer patients
Different immune functions of peripheral blood, regional lymph node, and tumor infiltrating lymphocytes in lung cancer patients
复制标题
肺癌患者外周血、区域淋巴结及肿瘤浸润淋巴细胞的不同免疫功能
作者：
Hiroshige Nakamura;K. Ishiguro;T. Mori
检测肺癌患者外周血（PBL）、区域淋巴结（RLNL）和肿瘤浸润淋巴细胞（TIL）的免疫功能。PBL中自然杀伤（NK）细胞最多，NK活性最高，三组淋巴细胞中IFN-γ + rIL-2对NK活性的增强作用最强。PBL对广谱细胞系具有高的淋巴因子激活的杀伤（LAK）活性，对自体肿瘤细胞具有中等活性，其效应靶（ET）比增加，但三组淋巴细胞产生IL-2的能力最低。与肿瘤转移无关的RLNL的NK细胞数量少，NK活性低于PBL，而LAK活性与PBL相近，但不高于PBL。RLNL产生IL-2的能力在三组淋巴细胞中最强。与肿瘤转移相关的RLNL活性均低于与肿瘤转移无关的RLNL活性。TIL仅由T细胞组成，特别是细胞毒性/抑制性T淋巴细胞。TIL的NK活性和淋巴细胞转化率均低于其他各组。TIL的LAK活性因病例而异，其中3例对自体肿瘤细胞的杀伤活性最高。这些结果表明，PBL、RLNL和TIL在肺癌中具有特征性的淋巴细胞亚群和不同的宿主免疫应答功能。特征性免疫应答的有效增强将导致更有效的整体癌症治疗。
Immune functions of peripheral blood (PBL), regional lymph node (RLNL), and tumor infiltrating lymphocytes (TIL) were evaluated in lung cancer patients. PBL had many natural killer (NK) cells and the highest NK activity, and it showed the highest augmentation of NK activity by interferon‐SgM (IFN‐γ) + recombinant interleukin‐2 (rIL‐2) among the three groups of lymphocytes. PBL had high lymphokine‐activated killer (LAK) activity of against a broad spectrum of cell lines and moderate activity against autologous tumor cells by increased effector to target (ET) ratio but the lowest ability of IL‐2 production of the three groups of lymphocytes. The RLNL not associated with tumor metastasis had a few NK cells and lower NK activity than PBL, but its LAK activity was almost the same but not greater than that of PBL. RLNL had the highest ability of IL‐2 production among the three groups of lymphocytes. All activities of RLNL associated with tumor metastasis were lower than those not associated with tumor metastasis. TIL exclusively consisted of T‐cells, especially cytotoxic/suppressor T‐Iymphocytes. NK activity and lymphocyte blastogenesis of TIL were lower than those of other groups. The LAK activity of TIL differed greatly with the case, and it was the highest against autologous tumor cells among the three groups of lymphocytes in three of eight cases. These findings showed that PBL, RLNL, and TIL had characteristic subpopulations of lymphocytes and different functions of host immune responses in lung cancer. Efficient augmentation of the characteristic immune responses will lead to a more effective total cancer therapy.
从卵巢腹水肿瘤患者中分离出的肿瘤相关淋巴细胞和外周血淋巴细胞的淋巴因子激活的杀伤活性。
DOI：
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发表时间：
1986
期刊：
Journal of the National Cancer Institute
影响因子：
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作者：
Allavena,P;Zanaboni,F;Rossini,S;Merendino,A;Bonazzi,C;Vassena,L;Mangioni,C;Mantovani,A
通讯作者：
Mantovani,A