Chronic effects of cannabis on sensory gating
Chronic effects of cannabis on sensory gating
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DOI：
10.1016/j.ijpsycho.2013.04.015
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发表时间：
2013-09-01
影响因子：
3
通讯作者：
Solowij, Nadia
中科院分区：
文献类型：
--
作者：
Broyd, Samantha J.;Greenwood, Lisa-marie;Solowij, Nadia
长期使用大麻与神经认知障碍、大脑结构和功能改变以及精神病有关。本研究调查了长期吸食大麻对经常吸食者P50感觉门控的影响，并探讨了感觉门控、大麻吸毒史与精神病样症状发生的关系。20名对照组和21名普通大麻吸毒者完成了P50配对点击(S1和S2)范式，配对间隔为9 S，比较两组的P50波幅与S1和S2的波幅、P50比率(S2/S1)和P50差值(S1-S2)。虽然大麻使用者总体上在P50指标上与对照组没有不同，但根据P50比率和不同分数(包括控制烟草使用后)的指数，常规使用时间的延长与感觉门控的更大损害有关。研究发现，与短期吸食大麻的人和对照组相比，长期吸食大麻的人的感官门控比率和差异分数更低。P50指标与大麻使用者的精神病样症状的任何指标都没有显著的相关性。这些结果表明，长期接触大麻会导致长期吸食大麻的P50感觉门控受损。虽然这些缺陷可能早于大麻使用，并反映了对大麻使用的脆弱性，但它们与大麻使用年数增加的联系表明，情况并非如此。P50感觉门控受损的比率在精神分裂症患者中也有报道，可能表明类似的潜在病理。(C)2013爱思唯尔B.V.保留所有权利。
Chronic cannabis use has been associated with neurocognitive deficits, alterations in brain structure and function, and with psychosis. This study investigated the effects of chronic cannabis use on P50 sensory-gating in regular users, and explored the association between sensory gating, cannabis use history and the development of psychotic-like symptoms. Twenty controls and 21 regular cannabis users completed a P50 paired-click (S1 and S2) paradigm with an inter-pair interval of 9 s. The groups were compared on P50 amplitude to S1 and S2, P50 ratio (S2/S1) and P50 difference score (S1-S2). While cannabis users overall did not differ from controls on P50 measures, prolonged duration of regular use was associated with greater impairment in sensory gating as indexed by both P50 ratio and difference scores (including after controlling for tobacco use). Long-term cannabis users were found to have worse sensory gating ratios and difference scores compared to short-term users and controls. P50 metrics did not correlate significantly with any measure of psychotic-like symptoms in cannabis users. These results suggest that prolonged exposure to cannabis results in impaired P50 sensory-gating in long-term cannabis users. While it is possible that these deficits may have pre-dated cannabis use and reflect a vulnerability to cannabis use, their association with increasing years of cannabis use suggests that this it not the case. Impaired P50 sensory-gating ratios have also been reported in patients with schizophrenia and may indicate a similar underlying pathology. (C) 2013 Elsevier B.V. All rights reserved.