Dichotomous effect of aerosolized hyaluronan in a hamster model of endotoxin-induced lung injury
Dichotomous effect of aerosolized hyaluronan in a hamster model of endotoxin-induced lung injury
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DOI：
10.1080/01902140600574942
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发表时间：
2005-11-01
影响因子：
1.7
通讯作者：
Cantor, JO
中科院分区：
文献类型：
--
作者：
Nadkarni, PP;Kulkarni, GS;Cantor, JO
本实验室先前已证明吸入雾化低分子量（150-kDa）透明质酸（HA）可预防实验诱导的肺气肿，且无相关毒性。然而，其他研究人员发现低分子量HA可能是促炎性的，促使作者确定雾化HA是否可能在涉及向仓鼠内毒素滴注的不同肺损伤模型中增强肺部炎症。结果表明，暴露于HA后内毒素管理显着增加肺部炎症，而预处理与HA有相反的效果。
Inhalation of aerosolized low-molecular weight (150-kDa) hyaluronan (HA) was previously shown by this laboratory to prevent experimentally induced pulmonary emphysema without associated toxicity. Nevertheless, other investigators have found that low-molecular-weight HA may be proinflammatory, prompting the authors to determine if aerosolized HA could possibly enhance pulmonary inflammation in a different model of lung injury involving intratracheal instillation of endotoxin to hamsters. Results indicate that exposure to HA following endotoxin administration significantly increased lung inflammation, whereas pretreatment with HA had the opposite effect.