Registry-based case-control study of cancer in California firefighters
Registry-based case-control study of cancer in California firefighters
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DOI：
10.1002/ajim.20446
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发表时间：
2007-05-01
影响因子：
3.5
通讯作者：
Bates, Michael N.
中科院分区：
文献类型：
--
作者：
Bates, Michael N.
消防员是否会增加某些癌症的癌症风险还没有达成共识。以前的研究规模很小，主要是调查癌症死亡率，并表明脑癌、膀胱癌、睾丸癌、前列腺癌、甲状腺癌和结肠直肠癌、白血病和黑色素瘤的风险增加。方法收集1988-2003年加州登记的所有男性癌症病例。消防员从职业和行业文本字段中识别。Logistic回归分析使用其他癌症作为对照。结果在804，000份合格记录中，3，659份以消防为职业。消防与睾丸癌（比值比= 1.54，95%置信区间：1.18-2.02）、黑色素瘤（1.50，1.33-1.70）、脑癌（1.35，1.06-1.72）、食管癌（1.48，1.14-1.91）和前列腺癌（1.22，1.12-1.33）相关。结论：使用其他癌症对照和缺乏职业史可能使相对风险偏向零。然而，这项研究，其中包含更多的消防员癌症比以往任何流行病学研究，产生的证据支持一些先前的假设。Am. J. Ind. Med. 50：339-344，2007. (C)2007 Wiley-Liss，Inc.
Background There is no consensus whether firefighters are at increased cancer risk for particular cancers. Previous studies have been small, mostly investigated cancer mortality, and suggested increased risks for brain, bladder, testicular, prostate, thyroid and colo-rectal cancers, leukemia, and melanoma. Methods Records of all male cancers registered in California during 1988-2003 were obtained. Firefighters were identified from occupation and industry text fields. Logistic regression analysis used other cancers as controls. Results Of the 804,000 eligible records, 3,659 had firefighting as their occupation. Firefighting was associated with testicular cancer (odds ratio = 1.54, 95% confidence interval: 1.18-2.02), melanoma (1.50, 1.33-1.70), brain cancer (1.35, 1.06-1.72), esophageal cancer (1.48, 1.14-1.91), and prostate cancer (1.22, 1.12-1.33). Conclusions Use of other-cancer controls and lack of an occupational history may have biased relative risks towards the null. However, this study, which contained more firefighter cancers than any previous epidemiologic study, produced evidence supporting some prior hypotheses. Am. J. Ind. Med. 50:339-344, 2007. (C) 2007 Wiley-Liss, Inc.