Activation of p38 mitogen-activated protein kinase and c-Jun-NH2-terminal kinase by BMP-2 and their implication in the stimulation of osteoblastic cell differentiation
Activation of p38 mitogen-activated protein kinase and c-Jun-NH2-terminal kinase by BMP-2 and their implication in the stimulation of osteoblastic cell differentiation
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DOI：
10.1359/jbmr.2003.18.11.2060
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发表时间：
2003-11-01
影响因子：
6.2
通讯作者：
Caverzasio, J
中科院分区：
文献类型：
--
作者：
Guicheux, J;Lemonnier, J;Caverzasio, J
成骨细胞分化中的信号转导机制仍不清楚。本研究进一步探讨BMP-2诱导成骨细胞分化的机制。我们报道BMP-2可以激活成骨细胞中的JNK和p38，并提供证据表明这些MAP激酶在调节碱性磷酸酶和骨钙素表达中具有不同的作用。
Signaling involved in osteoblastic cell differentiation remains largely unknown. This study further investigates mechanisms involved in BMP-2-induced osteoblastic cell differentiation. We report that BMP-2 can activate JNK and p38 in osteoblastic cells and provide evidences that these MAP kinases have distinct roles in regulating alkaline phosphatase and osteocalcin expression.