Trends in leptospirosis epidemiology in France. Sixty-six years of passive serological surveillance from 1920 to 2003
Trends in leptospirosis epidemiology in France. Sixty-six years of passive serological surveillance from 1920 to 2003
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DOI：
10.1016/j.ijid.2005.02.010
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发表时间：
2006-03-01
影响因子：
8.4
通讯作者：
Postic, D
中科院分区：
文献类型：
--
作者：
Baranton, G;Postic, D
目标：过去几十年来，西欧钩端螺旋体病（一种世界性人畜共患病）的发病率显着下降。我们的目的是分析巴斯德研究所从 1920 年至 2003 年收集的所有可靠数据，以更准确地评估法国钩端螺旋体病发病率的演变。方法：早在 1920 年使用的被动监测系统就可以评估钩端螺旋体病的发病率。从微凝集程序推断出的血清学结果用于评估疾病发病率的变化以及与人类疾病有关的钩端螺旋体血清群的进化。结果：未观察到钩端螺旋体病病例数或疾病发病率的显着变化。然而，20世纪70年代的特点是发生率相当低。天气在改变淡水丰度、啮齿动物数量和人类行为方面发挥着重要作用。然而，天气的影响并不是影响发病率的唯一因素。没有明显的周期性变化。结论：虽然法国是欧洲钩端螺旋体病发病率最高的国家，但对66年来收集的血清学数据的分析使我们得出结论，法国的发病率正在缓慢下降。(c) 2005年国际传染病学会。由爱思唯尔有限公司出版。保留所有权利。
Objectives: The incidence of leptospirosis, a worldwide zoonosis, has significantly decreased in Western Europe during the last decades. Our aim was to analyse all reliable data collected at the Institut Pasteur from 1920 to 2003 to evaluate more precisely the evolution of the incidence of leptospirosis in France.Methods: The passive surveillance system used as early as 1920 allows the evaluation of teptospirosis incidence. Serological results inferred from the microagglutination procedure were used to evaluate variation in the incidence of the disease and the evolution of the Leptospira serogroups involved in the human disease.Results: No significant variation either in the number of leptospirosis cases or in the incidence of the disease was observed. However, the period of the 1970s was characterized by a rather tow incidence. The weather plays a major role by modifying fresh water abundance, rodent populations and human behaviour. However the weather's influence is not the sole factor involved in the incidence rate. No cyclic variation was evident.Conclusion: Although France has the highest incidence of teptospirosis in Europe, the analysis of serological data collected over 66 years has allowed us to conclude that in France, the incidence is slowly decreasing.(c) 2005 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.