The human HNRPD locus maps to 4q21 and encodes a highly conserved protein
The human HNRPD locus maps to 4q21 and encodes a highly conserved protein
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DOI：
10.1006/geno.1998.5237
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发表时间：
1998-05-01
期刊：
影响因子：
4.4
通讯作者：
Maizels, N
中科院分区：
文献类型：
--
作者：
Dempsey, LA;Li, MJ;Maizels, N
hnRNP D蛋白在体内和体外都与核酸相互作用。像许多其他与RNA相互作用的蛋白质一样，它含有RBD（或“RRM”）结构域和arg-gly-gly （RGG）基序。我们研究了编码hnRNP D蛋白的人和小鼠基因的组织和定位。将hnRNP - D蛋白在人和小鼠中的预测序列进行比较，结果表明两者的相同度为96.9%（相似度为98.9%）。人类HNRPD基因的序列分析表明，该蛋白由8个外显子编码，另外两个外显子指定了3' UTR中的序列。两个编码外显子的使用是由HNRPD mRNA的选择性剪接决定的。人类HNRPD基因定位于4q21。小鼠Hnrpd基因定位于3号染色体的F区，与人类的4q21区同源。(C) 1998学术出版社。
The hnRNP D protein interacts with nucleic acids both in vivo and in vitro. Like many other proteins that interact with RNA, it contains RBD (or "RRM") domains and arg-gly-gly (RGG) motifs, We have examined the organization and localization of the human and murine genes that encode the hnRNP D protein. Comparison of the predicted sequences of the hnRNP D proteins in human and mouse shows that they are 96.9% identical (98.9% similar). This very high level of conservation suggests a critical function for hnRNP D, Sequence analysis of the human HNRPD gene shows that the protein is encoded by eight exons and that two additional exons specify sequences in the 3' UTR. Use of two of the coding exons is determined by alternative splicing of the HNRPD mRNA. The human HNRPD gene maps to 4q21. The mouse Hnrpd gene maps to the F region of chromosome 3, which is syntenic with the human 4q21 region. (C) 1998 Academic Press.