Acute side effects of surfactant treatment
Acute side effects of surfactant treatment
复制标题
表面活性剂治疗的急性副作用
DOI：
10.1515/jpm.2002.018
复制
发表时间：
2002
影响因子：
3.1
通讯作者：
G. Jorch
中科院分区：
文献类型：
--
作者：
R. Hentschel;G. Jorch
摘要越来越多的动物和人体研究表明，表面活性剂的应用可能对脑灌注产生重大影响。这些影响可能是由于直接的肺或血液动力学变化（或两者的组合），但也可能是由于血液气体的快速变化。表面活性剂的类型和给药方式似乎起着重要作用。总结了相关文献的结果，特别强调如何避免早产儿表面活性剂治疗的潜在有害副作用。
Abstract There is increasing evidence from studies on animals and humans that surfactant administration may have a great impact on cerebral perfusion. These effects may result from direct pulmonary or hemodynamic changes (or a combination of both), but may also be due to rapid alterations of blood gases. Type of surfactant and mode of administration seem to play an important role. Results from the pertinent literature are summarised with a special emphasis on how to avoid potentially harmful side effects of surfactant therapy in preterm infants.