High-resolution whole-body magnetic resonance image tumor staging with the use of parallel imaging versus dual-modality positron emission tomography-computed tomography - Experience on a 32-channel system
High-resolution whole-body magnetic resonance image tumor staging with the use of parallel imaging versus dual-modality positron emission tomography-computed tomography - Experience on a 32-channel system
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DOI：
10.1097/01.rli.0000185878.61270.b0
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发表时间：
2005-12-01
影响因子：
6.7
通讯作者：
Schoenberg, SO
中科院分区：
文献类型：
--
作者：
Schmidt, GP;Baur-Melnyk, A;Schoenberg, SO
目的：本研究的目的是比较全身磁共振成像（WB-MRI）采用平行成像（PAT）和正电子发射断层扫描-计算机断层扫描（PET-CT）对各种恶性肿瘤分期的准确性。材料与方法：在一项前瞻性研究中，41例肿瘤疾病患者采用[F-18]-氟-2-脱氧-d -葡萄糖PET-CT进行肿瘤分期，并在32通道扫描仪上使用PAT进行WB-MRI。进行5个身体水平的冠状T1w和STIR序列，肺轴向急速成像，以及肝、脑和腹部的增强T1w序列。以组织学结果和6个月内的放射学随访作为参考标准，在单独的共识读数中评估两种方式的TNM分期。结果：原发肿瘤3例，复发肿瘤4例；WB-MRI未发现1例复发肿瘤。PET-CT和WB-MRI分别检测到60个良性和60个恶性淋巴结，分别为98%和83%的敏感性和80%/75%的特异性。PET-CT的灵敏度/特异性为82%，WB-MRI的灵敏度/特异性为96% /82%。PET-CT和WB-MRI对TNM分期的准确性分别为96%和91%。结论：W13-MRI和PET-CT是诊断肿瘤分期可靠的影像学手段。WB-MRI对远处转移的检测高度敏感；PET-CT在淋巴结分期方面具有优势。PAT使高分辨率W13-MRI在不到1小时内成为可能。
Objective: The objective of this study was to compare the accuracy in staging of various malignant tumors with whole-body magnetic resonance imaging (WB-MRI) using parallel imaging (PAT) and positron emission tomography-computed tomography (PET-CT).Materials and Methods: In a prospective study, 41 patients with oncologic diseases underwent [F-18]-fluoro-2-deoxy-D-glucose PET-CT for tumor staging and WB-MRI on a 32-channel-scanner with the use of PAT. Coronal T1w and STIR sequences at 5 body levels, axial HASTE imaging of the lung, and contrast-enhanced T1w sequences of the liver, brain, and abdomen were performed. TNM stage was assessed for both modalities in a separate consensus reading using histologic results and radiologic follow up within 6 months as the standard of reference.Results: Three primary and 4 recurrent tumors were detected; one recurrent tumor was missed with WB-MRI. Sixty benign and 60 malignant lymph nodes were detected with a sensitivity of 98% and specificity of 83% for PET-CT and 80%/75% for WB-MRI, respectively. One hundred ninety-one malignant and 77 benign distant lesions were detected with a sensitivity/specificity of 82% for PET-CT and 96'Yo/82% for WB-MRI. Accuracy for correct TNM staging was 96% for PET-CT and 91% for WB-MRI.Conclusion: W13-MRI and PET-CT are reliable imaging modalities for tumor staging. WB-MRI is highly sensitive in detecting distant inetastases; PET-CT is superior in lymph node staging. PAT makes high-resolution W13-MRI feasible within less than 1 hour.