Plasma levels of interleukin-6 and C-reactive protein are associated with physical inactivity independent of obesity
Plasma levels of interleukin-6 and C-reactive protein are associated with physical inactivity independent of obesity
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DOI：
10.1111/j.1600-0838.2006.00602.x
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发表时间：
2007-10-01
影响因子：
4.1
通讯作者：
Pedersen, B. K.
中科院分区：
文献类型：
--
作者：
Fischer, C. P.;Berntsen, A.;Pedersen, B. K.
人们认识到，从身体缺乏活动和肥胖到生活方式相关疾病的路径涉及低度炎症，血浆炎症标志物水平升高表明了这种炎症。有趣的是，收缩骨骼肌是急性运动时循环白细胞介素 6 (IL-6) 的主要来源，但在受过训练的受试者中，其反应明显较低。由于 C 反应蛋白 (CRP) 是由 IL-6 诱导的，因此我们假设与生活方式相关发病率相关的其他炎症标志物相比，IL-6 和 CRP 的基础水平反映了定期体力活动的程度。测量健康非糖尿病男性和女性 (n=84) 的空腹血浆/血清 IL-6、IL-18、CRP、肿瘤坏死因子-α (TNF-α)、可溶性 TNF 受体 II (sTNF-RII) 和脂联素水平。通过访谈评估休闲时间体力活动量（LTPA）。肥胖与胰岛素、C 肽、甘油三酯、低密度脂蛋白、IL-6、CRP 和脂联素升高相关（均 P < 0.05）。重要的是，缺乏体力活动与 C 肽 (P=0.036)、IL-6 (P=0.014) 和 CRP (P=0.007) 升高相关，与肥胖、年龄、性别和吸烟无关。此外，LTPA 评分与 IL-6 (P=0.017) 和 CRP (P=0.005) 呈负相关，但与其他标记均不相关。结果表明，低水平的 IL-6 和 CRP（而非 IL-18、TNF-α、sTNF-RII 或脂联素）反映了规律的体力活动。
It is recognized that the path from physical inactivity and obesity to lifestyle-related diseases involves low-grade inflammation, indicated by elevated plasma levels of inflammatory markers. Interestingly, contracting skeletal muscle is a major source of circulating interleukin-6 (IL-6) in response to acute exercise, but with a markedly lower response in trained subjects. As C-reactive protein (CRP) is induced by IL-6, we hypothesized that basal levels of IL-6 and CRP reflect the degree of regular physical activity when compared with other markers of inflammation associated with lifestyle-related morbidity. Fasting plasma/serum levels of IL-6, IL-18, CRP, tumur necrosis factor-alpha (TNF-alpha), soluble TNF receptor II (sTNF-RII), and adiponectin were measured in healthy non-diabetic men and women (n=84). The amount of leisure-time physical activity (LTPA) was assessed by interview. Obesity was associated with elevated insulin, C-peptide, triglycerides, low-density lipoprotein, IL-6, CRP, and adiponectin (all P < 0.05). Importantly, physical inactivity was associated with elevated C-peptide (P=0.036), IL-6 (P=0.014), and CRP (P=0.007) independent of obesity, age, gender, and smoking. Furthermore, the LTPA score was inversely associated with IL-6 (P=0.017) and CRP (P=0.005), but with neither of the other markers. The results indicate that low levels of IL-6 and CRP - not IL-18, TNF-alpha, sTNF-RII, or adiponectin - reflect regular physical activity.