Dissociation of the functional relevance of different pre-stimulus oscillatory activity for memory formation

Dissociation of the functional relevance of different pre-stimulus oscillatory activity for memory formation
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不同刺激前振荡活动与记忆形成的功能相关性的分离

DOI:
10.1016/j.neuroimage.2015.10.037
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发表时间:
2015
期刊:
影响因子:
5.7
通讯作者:
Salari
Salari
中科院分区:
医学1区
文献类型:
--
作者:
Salari

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在传入刺激之前的神经组装状态调节随后呈现的刺激的处理。对于人类记忆的形成,已经讨论了不同频率范围内振荡脑活动的作用,但无法建立更多的功能关系。在本实验I中,观察到在对后来记住的刺激进行编码的过程中,刺激前θ-(3-7 Hz)和β-(13-17 Hz)频带振荡的增加。为了建立更直接的功能关系,我们采用了一种新的脑机接口(BCI)方法,结合不同活动水平的自适应刺激呈现,实时选择性地检测振荡活动。因此,在第二个实验中,脑机接口被用来呈现视觉刺激具有高的时间分辨率直接在定义的大脑状态的β或θ带活动。随后的处理的刺激的质量进行了评估,在行为水平上的惊喜识别任务。结果显示,记忆性能的变化与刺激前β-而不是θ-波段振荡的量直接相关,这表明β-波段振荡与记忆编码的功能相关。因此,脑机接口的方法,使更多的功能分化的有效作用,正在进行的振荡活动。
The state of a neural assembly preceding an incoming stimulus modulates the processing of that subsequently presented stimuli. For human memory formation, the role of oscillatory brain activity within different frequency ranges has been discussed but a more functional relation could not be established. In the present Experiment I, an increase of pre-stimulus theta- (3–7 Hz) and beta- (13–17 Hz) band oscillations during encoding for later remembered stimuli was observed. To establish a more direct functional relation, we adopted a novel brain–computer-interface (BCI) method to selectively detect oscillatory activity in real-time combined with an adaptive stimulus presentation at different levels of activity. Therefore, in the second experiment the BCI was used to present the visual stimuli with a high temporal resolution directly within defined brain states of beta- or theta-band activity. The quality of the subsequent processing of the stimuli was assessed at the behavioral level with a surprise recognition task. Results revealed a variation of memory performance in direct relation to the amount of pre-stimulus beta- but not theta-band oscillations, suggesting a functional relevance of beta-band oscillations for memory encoding. Thus, the BCI method enabled a more functional differentiation of the effective role of ongoing oscillatory activity.
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