Some temporal and parietal cortical connections converge in CA1 of the primate hippocampus.
Some temporal and parietal cortical connections converge in CA1 of the primate hippocampus.
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DOI：
10.1093/cercor/9.3.232
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发表时间：
1999-04
期刊：
影响因子：
3.7
通讯作者：
K. Rockland;G. W. Hoesen
中科院分区：
文献类型：
--
作者：
K. Rockland;G. W. Hoesen
多模态皮层的大部分通过向内嗅皮层的收敛输入投射到海马体形成。本研究报告了一个额外的通路，即几个皮质区域直接投射到CA1。这些是顶骨区7a和7b，枕颞沟（OTS）内侧的TF区域，以及枕颞沟外侧的受限区域，可能是腹内侧TE区域的一部分。这些特殊的皮质区域与视觉空间过程有关；它们在CA1内的投射和收敛可能对“视野”的阐述，对海马体形成在地形学习和记忆中的假设作用，或在复杂的视觉空间关系背景下对物体的快照识别具有重要意义。前庭和视觉输入（分别来自7b区和7a区）的汇合将支持先前的生理学发现，即海马神经元对全身运动和环境视图的组合做出反应。直接的皮质-海马连接是广泛分散的，特别是那些来自颞区的连接，它延伸到海马主体的大部分前后轴。不同的连接可能影响大量的CA1锥体神经元，这与这些神经元参与连接编码的建议一致。腹内侧TE的同一区域，除了与CA1的直接连接外，也产生对V1区域的直接投影，并且可能对应于功能上专门的细分，可能是VTF的一部分。
Large sectors of polymodal cortex project to the hippocampal formation via convergent input to the entorhinal cortex. The present study reports an additional access route, whereby several cortical areas project directly to CA1. These are parietal areas 7a and 7b, area TF medial to the occipitotemporal sulcus (OTS), and a restricted area in the lateral bank of the OTS that may be part of ventromedial area TE. These particular cortical areas are implicated in visuospatial processes; and their projection to and convergence within CA1 may be significant for the elaboration of 'view fields', for the postulated role of the hippocampal formation in topographic learning and memory, or for the snapshot identification of objects in the setting of complex visuospatial relationships. Convergence of vestibular and visual inputs (from areas 7b and 7a respectively) would support previous physiological findings that hippocampal neurons respond to combinations of whole-body motion and a view of the environment. The direct corticohippocampal connections are widely divergent, especially those from the temporal areas, which extend over much of the anteroposterior axis of the hippocampal main body. Divergent connections potentially influence large populations of CA1 pyramidal neurons, consistent with the suggestion that these neurons are involved in conjunctive coding. The same region of ventromedial TE, besides the direct connections to CA1, also gives rise to direct projections to area V1, and may correspond to a functionally specialized subdivision, perhaps part of VTF.