LUNG MECHANICS IN NORMAL INFANTS AND INFANTS WITH CONGENITAL HEART-DISEASE
LUNG MECHANICS IN NORMAL INFANTS AND INFANTS WITH CONGENITAL HEART-DISEASE
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DOI：
10.1136/adc.47.255.707
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发表时间：
1972-01-01
影响因子：
5.2
通讯作者：
HOWLETT, G
中科院分区：
文献类型：
--
作者：
HOWLETT, G
本文报告24例正常婴儿和28例1 ~ 32周先天性心脏病婴儿的肺力学研究结果。两组的身高和体重相匹配。婴儿先天性心脏病的诊断从简单的狭窄到复杂的间隔缺损和移位不等。对6例婴幼儿进行了手术前后的研究，以改善其血流动力学状况，用呼吸速度仪、积分仪和食管球囊测量肺顺应性和平均肺阻力，用体积描记法测量胸气量。结果被发现是可重复的，在个人和正常group.Thoracic气体容量与体重和肺阻力的先天性心脏病的婴儿是正常的，但肺顺应性往往是异常的，即使与肺容量。顺应性的变化不仅与肺血流量或压力有关，而且与肺血过多或血过少的放射学评估有关，血过多越多，顺应性越低。手术适当地改变了放射学分级和顺应性。据推测，肺的弹性性质的变化与肺毛细血管血容量的变化有关。
The results of a study of pulmonary mechanics in 24 normal infants and 28 infants with congenital heart disease aged 1 to 32 weeks are presented. The two groups were matched for length and weight. The diagnosis of the infants with congenital heart disease varied from simple stenoses to complex septal defects and transpositions. 6 infants were studied before and after operation designed to improve their haemodynamic situation.Pulmonary compliance and mean pulmonary resistance were measured using a pneumotachygraph, integrator, and oesophageal balloon; thoracic gas volume was measured by the plethysmographic method. Results were found to be reproducible both in the individual and within the normal group.Thoracic gas volume in relation to weight and pulmonary resistance were normal in the infants with congenital heart disease, but the pulmonary compliance was often abnormal even when related to lung volume. The change in compliance was not simply related to pulmonary blood flow or pressure but was related to the radiological assessment of pulmonary plethora or oligaemia—the more plethoric the lower the compliance. Surgery altered both the radiological grading and the compliance appropriately. It is postulated that changes in the elastic properties of the lungs are related to changes in the pulmonary capillary blood volume.