3-Ethyl-2,7-dimethyl octane, a testosterone dependent unique urinary sex pheromone in male mouse (Mus musculus)
3-Ethyl-2,7-dimethyl octane, a testosterone dependent unique urinary sex pheromone in male mouse (Mus musculus)
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DOI：
10.1016/j.anireprosci.2004.11.001
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发表时间：
2005-06-01
影响因子：
2.2
通讯作者：
Archunan, G
中科院分区：
文献类型：
--
作者：
Achiraman, S;Archunan, G
以前的研究表明，正常雄性小鼠的尿液含有五种独特的挥发性成分，即：3-环己烯-1-甲醇（I）; 3-氨基三唑（II）; 4-乙基苯酚（III）; 3-乙基-2，7-二甲基辛烷（IV）; 1-碘十一烷（V）。本研究的目的是找出这些男性特定的尿中化合物的生产是否是雄激素依赖性的。采用气相色谱-质谱法（GC-MS）分析去势和去势加睾酮给药雄性小鼠的尿液。尽管去势雄性尿液中含有10种可检测化合物，但去势雄性小鼠尿液中不存在完整雄性中存在的5种雄性特异性化合物。睾酮给药后，去势雄性动物中仅3-乙基-2，7-二甲基辛烷（IV）再次出现。我们先前的生物测定显示，这种化合物与吸引雌性有关。本研究表明，该化合物是一种雄性特有的挥发性线索，作为一种引诱性信息素，其产生受雄性激素的控制。(c)2004 Elsevier B. V.保留所有权利。
A previous investigation revealed that urine from normal male mice contained five unique volatile constituents; namely: 3-cyclohexene-1-methanol (I); 3-amino triazole (II); 4-ethyl phenol (III); 3ethyl-2,7-dimethyl octane (IV); 1-iodoundecane (V). The present study was designed to find out whether the production of these male specific urinary compounds was androgen-dependent. Urine of castrated and castrated plus testosterone-treated male mice was analyzed using gas chromatography linked mass spectrometry (GC-MS). Even though castrated male urine contained 10 detectable compounds, the five male specific compounds present in intact males were absent in castrated male mice urine. Only 3-ethyl-2,7-dimethyl octane (IV) reappeared following testosterone treatment into castrated males. Our earlier bioassay revealed that this compound was involved in attracting females. The present study concluded that this compound was a male specific volatile cue that acted as a releaser pheromone and its production was under the control of androgen. (c) 2004 Elsevier B.V. All rights reserved.