Higher functioning children with prenatal alcohol exposure: is there a specific neurocognitive profile?
Higher functioning children with prenatal alcohol exposure: is there a specific neurocognitive profile?
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产前酒精暴露的功能较高的儿童：是否存在特定的神经认知特征？
DOI：
10.1080/09297049.2012.713466
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
O'Connor,MaryJ
中科院分区：
文献类型：
--
作者：
Quattlebaum,JustinL;O'Connor,MaryJ
最近的尝试，以确定一个神经认知档案的儿童与产前酒精暴露（PAE），导致了一个新兴的“广义赤字”的概念化，其特点是分散的信息处理和整合的困难，而不是一个特定的配置文件。本研究探讨这一概念是否可以扩展到高功能的儿童与PAE谁是没有智力残疾，并解决了以前的研究的几个局限性。125名6-12岁的社交技能缺陷儿童，其中97人符合胎儿酒精谱系障碍（FASD）的诊断标准，接受了神经认知，情感，社会，行为和适应功能的全面，多信息评估。多变量方差分析检查PAE组和未暴露的对照组之间的功能差异，并控制和不控制儿童智商。结果表明，PAE组返回显着较差的分数比nonexposed组的每一个结构评估，包括执行功能，注意力，工作/视觉空间记忆，语言抽象，适应行为，情绪/行为功能，社会认知。这些差异在很大程度上保持控制后的智商和类似的，无论线人，虽然教师报告少一些组的差异。在PAE组内，未发现FASD亚型之间存在差异。这些结果提供了证据，扩展新兴的广义赤字概念化的儿童与PAE那些更高的功能没有全球性智力残疾的个人。
Recent attempts to identify a neurocognitive profile of children with prenatal alcohol exposure (PAE) have led to an emerging “generalized deficit” conceptualization marked by diffuse information processing and integration difficulties as opposed to a specific profile. This study examines whether this conceptualization can be extended to higher functioning children with PAE who are without intellectual disability and addresses several limitations of previous research. One hundred twenty-five children aged 6–12 years with social skills deficits, 97 of whom met diagnostic criteria for a Fetal Alcohol Spectrum Disorder (FASD), underwent a comprehensive, multi-informant assessment of neurocognitive, emotional, social, behavioral, and adaptive functioning. Multivariate analyses of variance examined differences in functioning between the PAE group and a nonexposed comparison group with and without controlling for child IQ. Results indicated that the PAE group returned significantly poorer scores than the nonexposed group on every construct assessed, including executive functioning, attention, working/visuospatial memory, linguistic abstraction, adaptive behavior, emotional/behavioral functioning, and social cognition. These differences largely maintained after controlling for IQ and were similar regardless of informant, although teachers reported somewhat fewer group differences. Within the PAE group, no differences were found across FASD subtypes. These results provide evidence extending the emerging generalized deficit conceptualization of children with PAE to those higher functioning individuals without global intellectual disability.