The Calcium Binding Protein S100A11 and Its Roles in Diseases.
The Calcium Binding Protein S100A11 and Its Roles in Diseases.
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钙结合蛋白 S100A11 及其在疾病中的作用
DOI：
10.3389/fcell.2021.693262
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发表时间：
2021
影响因子：
5.5
通讯作者：
Liang B
中科院分区：
文献类型：
--
作者：
Zhang L;Zhu T;Miao H;Liang B
人类钙结合蛋白S100家族包含21个已知成员，每个成员的分子量在10至14 kDa之间。这些蛋白质的特征在于独特的螺旋-环-螺旋EF手基序，并且通常形成二聚体和多聚体。S100家族主要存在于脊椎动物中，在细胞内和细胞外发挥其生物学功能，作为钙传感器/结合蛋白。S100 A11是S100家族的成员，可介导响应于内部或外部刺激的信号转导，并且在不同的疾病如癌症、代谢性疾病、神经系统疾病和血管钙化中发挥各种作用。此外，它可以作为趋化剂在炎症性疾病中发挥作用。本文首先详细介绍了S100蛋白的发现及其结构特征，然后重点介绍了S100 A11在组织器官中的表达。我们还总结了它的生物活性和在不同疾病和信号通路中的作用，提供了迄今为止S100 A11研究的概述。
The calcium binding protein S100 family in humans contains 21 known members, with each possessing a molecular weight between 10 and 14 kDa. These proteins are characterized by a unique helix-loop-helix EF hand motif, and often form dimers and multimers. The S100 family mainly exists in vertebrates and exerts its biological functions both inside cells as a calcium sensor/binding protein, as well as outside cells. S100A11, a member of the S100 family, may mediate signal transduction in response to internal or external stimuli and it plays various roles in different diseases such as cancers, metabolic disease, neurological diseases, and vascular calcification. In addition, it can function as chemotactic agent in inflammatory disease. In this review, we first detail the discovery of S100 proteins and their structural features, and then specifically focus on the tissue and organ expression of S100A11. We also summarize its biological activities and roles in different disease and signaling pathways, providing an overview of S100A11 research thus far.
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影响因子：
11.8
作者：
Eden ER;Sanchez-Heras E;Tsapara A;Sobota A;Levine TP;Futter CE
通讯作者：
Futter CE
在表皮生长因子受体的加工过程中，膜联蛋白I在多个体体中被磷酸化。
影响因子：
7.8
作者：
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通讯作者：
Hopkins, C R
影响因子：
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作者：
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通讯作者：
Melle, Christian
影响因子：
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作者：
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通讯作者：
Terkeltaub, Robert A.
影响因子：
11.2
作者：
ALEXIANU, ME;HO, BK;APPEL, SH
通讯作者：
APPEL, SH