Inflammation and Joint Tissue Interactions in OA: Implications for Potential Therapeutic Approaches.
Inflammation and Joint Tissue Interactions in OA: Implications for Potential Therapeutic Approaches.
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DOI：
10.1155/2012/741582
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Zeng L
中科院分区：
文献类型：
--
作者：
Rainbow R;Ren W;Zeng L
骨关节炎（OA）软骨退化的发病机制是多因素的，涉及软骨及其周围组织之间的相互作用。这些相互作用调节促炎性精氨酸介导的软骨破坏，有助于OA进展以及软骨修复。本文综述了OA的发病机制，在关节中的多种组织类型的背景下，并讨论了这种复杂的组织相互作用的影响，在开发抗炎治疗OA的治疗。
It is increasingly recognized that the pathogenesis of cartilage degradation in osteoarthritis (OA) is multifactorial and involves the interactions between cartilage and its surrounding tissues. These interactions regulate proinflammatory cytokine-mediated cartilage destruction, contributing to OA progression as well as cartilage repair. This review explores the pathogenesis of OA in the context of the multiple tissue types in the joint and discusses the implications of such complex tissue interaction in the development of anti-inflammatory therapeutics for the treatment of OA.