Transgenerational effects of maternal exposure to chemicals on the functional development of the brain in the offspring
Transgenerational effects of maternal exposure to chemicals on the functional development of the brain in the offspring
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DOI：
10.1023/a:1018477809755
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发表时间：
1997-05-01
影响因子：
2.3
通讯作者：
Fujii, T
中科院分区：
文献类型：
--
作者：
Fujii, T
为了预防环境化学品对子代的健康风险，我们一直在对包括治疗药物在内的各种化学品进行风险评估。本文报道了母体暴露于精神活性药物、抗癌药物或除草剂对大鼠子代的功能影响，母体暴露于相当于单位体重治疗剂量的丙咪嗪可诱导雄性后代对氯丙嗪产生高热反应，当正常对照组大鼠表现出明显的体温过低时，暴露于乙琥胺导致由哺乳期正常母亲养育的年幼后代的玩耍打斗行为增加。在不同的妊娠阶段单次暴露于尼莫司汀或顺铂（抗癌药物）导致在妊娠早期暴露时生长加速。此外，顺铂暴露的大鼠情绪不稳定，表现出较短的潜伏期在一个开放的领域在婴儿期的第一行交叉。暴露于草铵膦铵，除草剂，在海马神经发生的时间的大鼠表现出减少的湿狗抖动响应红藻氨酸在6周龄，这些结果表明，母亲在怀孕期间暴露于化学品诱导各种功能异常的后代的大脑依赖于化学品的药理作用和妊娠阶段，即使是一个单一的曝光。
In order to prevent health risk from environmental chemicals, particularly for progeny, we have been performing a risk assessment for various chemicals including therapeutic agents, This paper reports the functional effects of maternal exposure to psychoactive drugs, anticancer drugs, or herbicides on the offspring of rats, Maternal exposure to imipramine in a dose equivalent to the therapeutic dose per unit body weight induced hyperthermic response to chlorpromazine in the male offspring, while normal control rats showed a marked hypothermia, Exposure to ethosuximide resulted in an increase in play fighting behavior in young offspring that was fostered by lactating normal mothers. Single exposures to nimustine or cisplatin, anticancer drugs, at a different gestational stage resulted in an acceleration of growth when exposed at the earlier stage of gestation. Moreover, cisplatin-exposed rats were emotionally unstable, showing a short latent time to the first line-crossing in an open-field during infantile period. The rats exposed to glufosinate ammonium, an herbicide, during the time of neurogenesis in the hippocampus showed a decrease in the wet-dog shakes response to kainic acid at six weeks of age, These results suggest that maternal exposure to chemicals during pregnancy induces a variety of functional abnormalities in the brain of the offspring dependent on the pharmacologic action of chemicals and the stage of gestation even with a single exposure.