Common polymorphisms in the glyoxalase-1 gene and their association with pro-thrombotic factors.
Common polymorphisms in the glyoxalase-1 gene and their association with pro-thrombotic factors.
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DOI：
10.3132/dvdr.2004.004
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发表时间：
2004-05-01
影响因子：
2.4
通讯作者：
Summers, Lucinda K M
中科院分区：
文献类型：
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作者：
Gale, Christopher P;Futers, T Simon;Summers, Lucinda K M
晚期糖基化终末产物(AGEs)在糖尿病中加速形成，并有助于大血管疾病的发展。它们的前体被乙醛酶系统解毒。乙醛酶-1基因的干扰可能会改变AGEs的相互作用，并影响促血栓形成因子。我们对89名健康先证者中的537名受试者进行乙草酸酶-1基因突变筛查和血栓前标志物检测。在翻译起始点的-7(C-T)和20203(C-A)位置发现了常见的单核苷酸多态(SNP)。这些SNP分别处于Hardy-Weinberg平衡(CC=105，CA=266，AA=148；p>；0.05；CC=126，CT=279，TT=114；p>；0.05)和连锁不平衡(D=27%，p
Advanced glycation endproducts (AGEs) form at an accelerated rate in diabetes and contribute to the development of macrovascular disease. Their precursors are detoxified by the glyoxalase system. Perturbations of the glyoxalase-1 gene may alter AGEs' interactions and affect pro-thrombotic factors. We screened the glyoxalase-1 gene for mutations and measured pro-thrombotic markers in 537 subjects from 89 healthy probands. Common single nucleotide polymorphisms (SNPs) were identified at positions -7 (C to T) and 20203 (C to A) from the translation start site. These SNPs were in Hardy-Weinberg equilibrium (CC=105, CA=266, AA=148; p>0.05; CC=126, CT=279, TT=114; p>0.05, respectively) and in linkage disequilibrium (D=27%, p