A common genetic target for environmental and heritable influences on aggressiveness in Drosophila
A common genetic target for environmental and heritable influences on aggressiveness in Drosophila
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DOI：
10.1073/pnas.0801327105
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发表时间：
2008-04-15
影响因子：
11.1
通讯作者：
Anderson, David J.
中科院分区：
文献类型：
--
作者：
Wang, Liming;Dankert, Heiko;Anderson, David J.
环境和遗传因素可以调节攻击性，但其影响的生物学机制在很大程度上是未知的。同种动物的社会经验抑制了脊椎动物和无脊椎动物的攻击性，包括果蝇。我们通过对社会隔离（攻击性）与社会经验（非攻击性）雄性果蝇的头部组织进行微阵列分析，寻找其表达水平与社会经验对果蝇攻击性影响相关的基因。在大约200个差异表达的基因中，只有一个也存在于先前通过针对攻击性差异对经历遗传选择的果蝇菌株进行谱分析而鉴定的基因组中[Dierick HA，Greenspan RJ（2006）Nat Genet 38：1023 - 1031]。该基因Cyp6a20编码细胞色素P450。社会经验增加Cyp6a20的表达，并以可逆的方式降低侵略性。在Cyp6a20突变体中，攻击性增加，但不社会孤立的苍蝇。这些数据确定了环境和遗传对攻击性影响的共同遗传目标。Cyp6a20在与信息素敏感嗅觉感受器相关的非神经元支持细胞亚群中表达，这表明社会经验可能通过调节信息素敏感性来影响攻击性。
Environmental and genetic factors can modulate aggressiveness, but the biological mechanisms underlying their influence are largely unknown. Social experience with conspecifics suppresses aggressiveness in both vertebrate and invertebrate species, including Drosophila. We searched for genes whose expression levels correlate with the influence of social experience on aggressiveness in Drosophila by performing microarray analysis of head tissue from socially isolated (aggressive) vs. socially experienced (non-aggressive) male flies. Among approximate to 200 differentially expressed genes, only one was also present in a gene set previously identified by profiling Drosophila strains subjected to genetic selection for differences in aggressiveness [Dierick HA, Greenspan RJ (2006) Nat Genet 38:1023-1031]. This gene, Cyp6a20, encodes a cytochrome P450. Social experience increased Cyp6a20 expression and decreased aggressiveness in a reversible manner. In Cyp6a20 mutants, aggressiveness was increased in group-housed but not socially isolated flies. These data identify a common genetic target for environmental and heritable influences on aggressiveness. Cyp6a20 is expressed in a subset of nonneuronal support cells associated with pheromone-sensing olfactory sensilla, suggesting that social experience may influence aggressiveness by regulating pheromone sensitivity.