Bioactive secondary metabolites isolated from the soft coral derived Penicillium sp. SCSIO 41038.
Bioactive secondary metabolites isolated from the soft coral derived Penicillium sp. SCSIO 41038.
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DOI：
10.1080/14786419.2023.2207133
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发表时间：
2023-05
影响因子：
2.2
通讯作者：
Huimin Li;Jieyi Long;Xueni Wang;Jianglian She;Yonghong Liu;Yun-qiu Li;Bin Yang
中科院分区：
文献类型：
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作者：
Huimin Li;Jieyi Long;Xueni Wang;Jianglian She;Yonghong Liu;Yun-qiu Li;Bin Yang
对青霉SCSIO 41038进行了化学研究，分离并鉴定了一种新的环匹阿尼酸型生物碱，speradine I（1），一种新的间苯三酚衍生物，speradine J（8），沿着13个已知化合物。它们的结构确定的基础上，广泛的光谱分析，并与文献中的数据进行比较。体外抗肿瘤活性（22 Rv 1和PC-3）和对乙酰胆碱酯酶（AChE）的抑制活性。
Chemical investigation of the Penicillium sp. SCSIO 41038 led to the isolation and characterization of one new cyclopiazonic acid-type alkaloid, speradine I (1), and one new phloroglucinol derivative, speradine J (8), along with 13 known compounds. Their structures were determined on the basis of extensive spectroscopic analysis, and by a comparison with data from the literature. All the compounds were evaluated for their antitumor (22Rv1 and PC-3) and enzyme inhibitory activity against acetylcholinesterase (AChE) in vitro.