Chelating agents for the binding of metal ions to macromolecules
Chelating agents for the binding of metal ions to macromolecules
复制标题
用于将金属离子与大分子结合的螯合剂
作者：
M. W. Sundberg;C. Meares;D. Goodwin;C. Diamanti
聚氨基羧酸盐螯合剂，例如乙二胺四乙酸 (EDTA)，可与许多重金属离子形成稳定的螯合物。这些金属离子表现出广泛的有用的光谱和放射性特性，例如电子吸收、电子和X射线的散射、电子顺磁共振光谱、核磁共振光谱中线展宽和化学位移的产生、相关伽马射线级联的发射以及各种放射性寿命和核辐射。其络合物可以以某种选定的方式与生物大分子相互作用的螯合剂的制备可以使金属离子作为生物系统探针的一些新应用成为可能。
POLYAMINOCARBOXYLATE chelating agents such as ethylene-diaminetetraacetic acid (EDTA) form stable chelate complexes with the ions of many heavy metals. These metal ions exhibit a wide range of useful spectral and radioactive properties, such as electronic absorption, scattering of electrons and X rays, electron paramagnetic resonance spectra, the production of line-broadening and chemical shifts in nuclear magnetic resonance spectra, the emission of correlated gamma-ray cascades and various radioactive lifetimes and nuclear radiations. The preparation of chelating agents whose complexes can interact, in some selected manner, with biological macromolecules could make possible several new applications of metal ions as probes of biological systems.