Implicit and explicit aspects of sequence learning in pre-symptomatic Huntington's disease
Implicit and explicit aspects of sequence learning in pre-symptomatic Huntington's disease
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DOI：
10.1016/j.parkreldis.2007.11.009
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发表时间：
2008-08-01
影响因子：
4.1
通讯作者：
Eidelberg, D.
中科院分区：
文献类型：
--
作者：
Ghilardi, M. F.;Silvestri, G.;Eidelberg, D.
学习障碍可能是亨廷顿病（HD）早期症状的一部分。在这里，我们的特点内隐和外显方面的序列学习在11个症状前HD基因携带者（pHD）和11个正常对照。受试者在数字化平板电脑上移动光标并执行以下任务：SEQ：学习预测两个块中目标序列的出现; VSEQ：通过关注显示器而不移动一个块来学习序列，并通过移动到连续块中的序列（VSEQ测试）。外显学习是用陈述性得分和预期动作的数量来衡量的。内隐学习被测量为反映在运动时间上的策略改变。到SEQ结束时，pHD组的正确预期运动次数和陈述性评分明显低于对照组，而在VSEQ和VSEQ测试中，这些指标均有所改善。在所有三项任务中，对照组的运动时间发生了变化，但pHD组没有变化。这些结果表明，序列学习的外显和内隐方面可能在运动症状发作前受损。然而，当注意力需求减少时，外显而非内隐的学习可能会改善。(C)2008爱思唯尔有限公司保留所有权利。
Learning deficits may be part of the early symptoms of Huntington's disease (HD). Here we characterized implicit and explicit aspects of sequence learning in 11 pre-symptomatic HD gene carriers (pHD) and 11 normal controls. Subjects moved a cursor on a digitizing tablet and performed the following tasks: SEQ: learning to anticipate the appearance of a target sequence in two blocks; VSEQ: learning a sequence by attending to the display without moving for one block, and by moving to the sequence in a successive block (VSEQ test). Explicit learning was measured with declarative scores and number of anticipatory movements. Implicit learning was measured as a strategy change reflected in movement time. By the end of SEQ, pHD had a significantly lower number of correct anticipatory movements and lower declarative scores than controls, while in VSEQ and VSEQ test these indices improved. During all three tasks, movement time changed in controls, but not in pHD. These results suggest that both explicit and implicit aspects of sequence learning may be impaired before the onset of motor symptoms. However, when attentional demands decrease, explicit, but not implicit, learning may improve. (C) 2008 Elsevier Ltd. All rights reserved.