Insights into the establishment of left-right asymmetries in vertebrates
Insights into the establishment of left-right asymmetries in vertebrates
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DOI：
10.1002/bdrc.20122
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发表时间：
2008-06-01
影响因子：
2.1
通讯作者：
Belmonte, Juan Carlos Izpisua
中科院分区：
文献类型：
--
作者：
Raya, Angel;Belmonte, Juan Carlos Izpisua
脊椎动物的身体平面虽然在外部基本上是对称的，但在内部器官的布置和位置上显示出许多左右的差异。这种在胚胎发生期间形成的左右不对称，由复杂的表观遗传学和遗传级联反应控制，将偏侧性信息传递给不同的胚胎结构和器官原基。脊椎动物胚胎间这些信息级联的一个关键和进化上保守的特征是，在早期体细胞发育阶段，信息从结节左侧传递到侧板中胚层。我们在这里回顾了关于调节这种转移的侧向性的机制的最新证据。此外，我们提出了一个左右轴规范的模型，该模型强调了节点作为侧向性信息的集成者的角色，以及向节点和从节点传递此类信息的机制的进化守恒性。
The body-plan of vertebrates, while exteriorly essentially symmetric along its medio-lateral plane, displays numerous left-right differences in the disposition and placement of internal organs. Such left-right asymmetries, established during embryogenesis, are controlled by complex epigenetic and genetic cascades that impart laterality information to the different embryo structures and organ primordia. A key and evolutionarily conserved feature of these information cascades among vertebrate embryos is the left-sided transfer of information from the node to the lateral plate mesoderm during early somitogenesis stages. We review here recent evidence concerning the mechanisms that regulate the laterality of such transfer. Furthermore, we propose a model of left-right axis specification that underscores the role of the node as an integrator of laterality information and the evolutionary conservation of the mechanisms that convey such information to and from the node.